教員情報 - 大山　彦光 | 埼玉医科大学

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研究課題・受託研究・科研費

学術雑誌

学会発表

専門医・専門性キーワード

（最終更新日：2025-07-29 20:20:54）

  オオヤマ　ゲンコウ   OYAMA Genko
  大山　彦光
   所属   埼玉医科大学医学部脳神経内科

職種教授

■ 研究課題・受託研究・科研費

1.	2012/04～2015/03	ニューロモデュレーションによる新規パーキンソン病治療法開発のための基礎研究基盤研究(C)
2.	2013/04～2015/03	光遺伝学を用いたパーキンソン病の新しいニューロモジュレーションの研究若手研究(B)
3.	2014/04～2017/03	脳深部刺激術における局所フィールド電位測定に基づく刺激プログラミング法の開発基盤研究(C)
4.	2015/04～2018/03	ニューロモデュレーション治療の最適化を目指すための神経細胞活動の疾患横断的解析基盤研究(C)
5.	2015/04～2018/03	光遺伝学とiPS細胞技術を応用したパーキンソン病の新規治療法の開発若手研究(B)
6.	2018/04～2021/03	光操作とiPS細胞を用いたパーキンソン病に対する自律調節性神経細胞移植療法の開発基盤研究(C)
7.	2021/04～2024/03	統合的3次元オンライン診療プラットフォームによる神経疾患診療のデジタル化の研究基盤研究(C)
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■ 学術雑誌

1.	学術雑誌(症例報告)	繰り返しのランダム皮膚生検で診断に至らなかった血管内大細胞型B細胞リンパ腫の1例 2025/06/26
2.	学術雑誌(原著)	Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity. 2025/03
3.	学術雑誌(原著)	Digital detection of Alzheimer's disease using smiles and conversations with a chatbot. 2024/11
4.	学術雑誌(総説)	【不随意運動・運動異常症の臨床】不随意運動の診方,所見の取り方,鑑別の進め方 2024/11
5.	学術雑誌(原著)	Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients. 2024/10
6.	学術雑誌(総説)	【リハビリテーション医療とDX(デジタルトランスフォーメーション)】パーキンソン病におけるリハビリテーション医療DX 2024/10
7.	学術雑誌(原著)	Subthalamic nucleus local field potential stability in patients with Parkinson's disease. 2024/09
8.	学術雑誌(その他)	パーキンソン病講座　新時代のパーキンソン病治療　笑顔で過ごす日常のために 2024/08
9.	学術雑誌(総説)	人工知能の臨床応用について 2024/07
10.	学術雑誌(総説)	【脳を調整する-新時代の治療技法-】脳神経内科疾患における脳深部刺激療法(DBS) 2024/06
11.	学術雑誌(総説)	【Parkinson病-臨床と研究の新展開(その2)】Parkinson病診療におけるAIの応用 2024/04
12.	学術雑誌(原著)	Real-world local field potential recordings in patients with deep brain stimulation for Parkinson's disease. 2024/03/06
13.	学術雑誌(原著)	Real-world local field potential recordings in patients with deep brain stimulation for Parkinson's disease. 2024/03/06
14.	学術雑誌(原著)	Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease. 2024/02/15
15.	学術雑誌(原著)	Efficacy and Safety of Elobixibat in Parkinson's Disease with Chronic Constipation: CONST-PD Study. 2024/01/24
16.	学術雑誌(原著)	A proof of concept: digital diary using 24-hour monitoring using wearable device for patients with Parkinson's disease in nursing homes. 2024
17.	学術雑誌(その他)	Editorial: Remote monitoring technologies in neurodegenerative movement disorders. 2024
18.	学術雑誌(原著)	Long-Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease. 2023/12
19.	学術雑誌(原著)	Three-dimensional gait analysis of the effect of directional steering on gait in patients with Parkinson's disease. 2023/09
20.	学術雑誌(原著)	Analytical and clinical validity of wearable, multi-sensor technology for assessment of motor function in patients with Parkinson's disease in Japan. 2023/03/14
21.	学術雑誌(原著)	A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease. 2023
22.	学術雑誌(原著)	Role of the subthalamic nucleus in perceiving and estimating the passage of time. 2023
23.	学術雑誌(原著)	Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis 2022/11/01
24.	学術雑誌(原著)	Impaired virtual space-tilting perception in Parkinson's disease with Pisa syndrome 2022/11
25.	学術雑誌(原著)	Continuous 24-h Levodopa-Carbidopa Intestinal Gel Infusion After a Levodopa Holiday Suppressed Refractory Dyskinesia Despite Increasing Levodopa Dose. 2022/09
26.	学術雑誌(原著)	Can AI make people happy? The effect of AI-based chatbot on smile and speech in Parkinson's disease. 2022/06
27.	学術雑誌(原著)	Deep Brain Stimulation for a Patient with Familial Parkinson's Disease Harboring <scp> CHCHD2 </scp> p. <scp>T61I</scp> 2022/03/04
28.	学術雑誌(原著)	White matter microstructures in Parkinson's disease with and without impulse control behaviors. 2022/03
29.	学術雑誌(原著)	Investigating the efficacy and safety of elobixibat, an ileal bile acid transporter inhibitor, in patients with Parkinson's disease with chronic constipation: a multicentre, placebo-controlled, randomised, double-blind, parallel-group stud (CONST-PD). 2022/02/11
30.	学術雑誌(原著)	Subthalamic deep brain stimulation in Parkinson's disease with SNCA mutations: Based on the follow-up to 10 years. 2022/01/18
31.	学術雑誌(原著)	Genotype-phenotype correlation of Parkinson's disease with PRKN variants. 2022/01/06
32.	学術雑誌(原著)	Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury. 2022
33.	学術雑誌(原著)	Short-Term Motor Outcomes in Parkinson's Disease after Subthalamic Nucleus Deep Brain Stimulation Combined with Post-Operative Rehabilitation: A Pre-Post Comparison Study. 2022
34.	学術雑誌(原著)	Varicella-zoster virus encephalitis resembling herpes simplex virus encephalitis. 2021/12/31
35.	学術雑誌(原著)	Current Status of Telemedicine for Parkinson’s Disease in Japan: A Single-Center Cross-Sectional Questionnaire Survey 2021/12/24
36.	学術雑誌(原著)	White matter and nigral alterations in multiple system atrophy-parkinsonian type. 2021/10/29
37.	学術雑誌(原著)	Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review. 2021/08
38.	学術雑誌(原著)	White matter alterations in Parkinson's disease with levodopa-induced dyskinesia. 2021/07/24
39.	学術雑誌(原著)	New modalities and directions for dystonia care. 2021/04
40.	学術雑誌(原著)	Clinical manifestations of Parkinson's disease harboring VPS35 retromer complex component p.D620N with long-term follow-up. 2021/03
41.	学術雑誌(原著)	Closed-loop programming using external responses for deep brain stimulation in Parkinson's disease. 2021/03
42.	学術雑誌(原著)	Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations. 2020/11/13
43.	学術雑誌(原著)	[Telemedicine in Neurological Diseases]. 2020/10
44.	学術雑誌(原著)	A Retrospective Imaging Evaluation of Presynaptic Dopaminergic Degeneration in Multiple System Atrophy with Levodopa Induced Dyskinesia. 2020/06/15
45.	学術雑誌(原著)	Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan. 2020/05/13
46.	学術雑誌(原著)	Neurocognitive and psychiatric disorders-related axonal degeneration in Parkinson's disease. 2020/05
47.	学術雑誌(原著)	Evaluation of white matter microstructure in patients with Parkinson's disease using microscopic fractional anisotropy. 2020/02
48.	学術雑誌(原著)	Graphic Summary of Movement Disorders Society Criteria for Progressive Supranuclear Palsy and Multiple Allocations eXtinction Rules. 2020/02
49.	学術雑誌(原著)	Rescue Levodopa/Carbidopa Intestinal Gel for Secondary Deep Brain Stimulation Failure. 2020/01
50.	学術雑誌(原著)	An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East. 2020
51.	学術雑誌(原著)	The absence of orthostatic heart rate increase is associated with cognitive impairment in Parkinson's disease. 2020
52.	学術雑誌(原著)	Convolutional neural network-based segmentation can help in assessing the substantia nigra in neuromelanin MRI. 2019/12
53.	学術雑誌(原著)	Free-Water Imaging in White and Gray Matter in Parkinson's Disease. 2019/08/05
54.	学術雑誌(原著)	Technique and outcome of percutaneous endoscopic transgastric jejunostomy for continuous infusion of levodopa-carbidopa intestinal gel for treatment of Parkinson's disease. 2019/06
55.	学術雑誌(原著)	A Randomized Crossover Pilot Study of Telemedicine Delivered via iPads in Parkinson's Disease. 2019
56.	学術雑誌(原著)	Balance and Gait Improvements of Postoperative Rehabilitation in Patients with Parkinson's Disease Treated with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS). 2019
57.	学術雑誌(原著)	Pilot feasibility study of a semi-automated three-dimensional scoring system for cervical dystonia. 2019
58.	学術雑誌(原著)	Zonisamide Administration Improves Fatty Acid β-Oxidation in Parkinson's Disease. 2018/12/29
59.	学術雑誌(原著)	Effect of subthalamic nucleus deep brain stimulation on visual scanning. 2018/11
60.	学術雑誌(原著)	The presence of cerebral microbleeds is associated with cognitive impairment in Parkinson's disease. 2018/10/15
61.	学術雑誌(原著)	GCH1 mutations in dopa-responsive dystonia and Parkinson's disease. 2018/08
62.	学術雑誌(原著)	Transdermal rotigotine patch in Parkinson's disease with a history of intestinal operation. 2018/06/15
63.	学術雑誌(原著)	Pilot Study of a Device to Induce the Hanger Reflex in Patients with Cervical Dystonia. 2018/05/15
64.	学術雑誌(原著)	Progressive multifocal leukoencephalopathy with immune reconstitution inflammatory syndrome following treatment for granulomatosis with polyangiitis 2018/05
65.	学術雑誌(原著)	Cerebral microbleeds and blood pressure abnormalities in Parkinson's disease. 2018/03
66.	学術雑誌(原著)	Dopamine transporter imaging predicts motor responsiveness to levodopa challenge in patients with Parkinson's disease: A pilot study of DATSCAN for subthalamic deep brain stimulation. 2018/02/15
67.	学術雑誌(原著)	Association between abnormal nocturnal blood pressure profile and dementia in Parkinson's disease. 2018/01
68.	学術雑誌(原著)	Istradefylline for Restless Legs Syndrome Associated with Parkinson's Disease. 2018
69.	学術雑誌(原著)	Dual use of rectangular and triangular waveforms in voltammetry using a carbon fiber microelectrode to differentiate norepinephrine from dopamine 2017/10/01
70.	学術雑誌(原著)	"Two odd targets" strategy in deep brain stimulation for Parkinson's disease with unilateral levodopa-induced dystonia 2017/07
71.	学術雑誌(原著)	Rescue pallidal stimulation for diphasic and stimulation-induced dyskinesia after successful subthalamic stimulation for Parkinson's disease 2017/07
72.	学術雑誌(原著)	Management of impulse control disorders with deep brain stimulation: A double-edged sword. 2017/03/15
73.	学術雑誌(原著)	Erratum to: A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics. 2017/02/20
74.	学術雑誌(原著)	[Deep Brain Stimulation for Parkinson Disease:Mechanisms and New Technology]. 2017/01
75.	学術雑誌(原著)	Deep brain stimulation for Parkinson's disease. 2017/01
76.	学術雑誌(原著)	Interleaving stimulation with a combination of bipolar and monopolar configurations for secondary failure of bilateral subthalamic stimulation in Parkinson's disease 2017/01
77.	学術雑誌(原著)	Current Topics in Deep Brain Stimulation for Parkinson Disease. 2016/10/15
78.	学術雑誌(原著)	Effect of zonisamide on post-traumatic Holmes' tremor 2016/09
79.	学術雑誌(原著)	A randomized double-blind multi-center trial of hydrogen water for Parkinson's disease: protocol and baseline characteristics. 2016/05/12
80.	学術雑誌(原著)	Atypical parkinsonism caused by Pro105Leu mutation of prion protein: A broad clinical spectrum. 2016/02
81.	学術雑誌(原著)	High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism. 2015/05
82.	学術雑誌(原著)	Low-frequency Versus High-frequency Subthalamic Nucleus Deep Brain Stimulation on Postural Control and Gait in Parkinson's Disease: A Quantitative Study 2015/01
83.	学術雑誌(原著)	Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease. 2014/11
84.	学術雑誌(原著)	Deep brain stimulation may improve quality of life in people with Parkinson's disease without affecting caregiver burden. 2014/02
85.	学術雑誌(原著)	Brittle Dyskinesia Following STN but not GPi Deep Brain Stimulation. 2014
86.	学術雑誌(原著)	Deep brain stimulation for tremor associated with underlying ataxia syndromes: a case series and discussion of issues. 2014
87.	学術雑誌(原著)	Rescue GPi-DBS for a Stroke-associated Hemiballism in a Patient with STN-DBS. 2014
88.	学術雑誌(原著)	Efficacy and safety of a once-daily extended-release formulation of pramipexole switched from an immediate-release formulation in patients with advanced Parkinson's disease: Results from an open-label study 2013/12
89.	学術雑誌(原著)	Standard strategies for diagnosis and treatment of patients with newly diagnosed Parkinson disease: JAPAN. 2013/12
90.	学術雑誌(原著)	Taking a Better History for Behavioral Issues Pre- and Post-Deep Brain Stimulation: Issues Missed by Standardized Scales 2013/01
91.	学術雑誌(原著)	[Mechanism of action for deep brain stimulation and electrical neuro-network modulation (ENM)]. 2013
92.	学術雑誌(原著)	A Novel DYT-5 Mutation with Phenotypic Variability within a Colombian Family. 2013
93.	学術雑誌(原著)	Differential and better response to deep brain stimulation of chorea compared to dystonia in Huntington's disease. 2013
94.	学術雑誌(原著)	Update on deep brain stimulation for movement disorders 2013
95.	学術雑誌(原著)	Validity of single tract microelectrode recording in subthalamic nucleus stimulation. 2013
96.	学術雑誌(原著)	GPi and STN deep brain stimulation can suppress dyskinesia in Parkinson's disease. 2012/08
97.	学術雑誌(原著)	Selection of Deep Brain Stimulation Candidates in Private Neurology Practices: Referral May Be Simpler than a Computerized Triage System 2012/05
98.	学術雑誌(原著)	Addiction-like manifestations and Parkinson's disease: a large single center 9-year experience. 2012/03
99.	学術雑誌(原著)	Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease? 2012
100.	学術雑誌(原著)	Effects of STN and GPi deep brain stimulation on impulse control disorders and dopamine dysregulation syndrome. 2012
101.	学術雑誌(原著)	Low-Frequency Deep Brain Stimulation for Dystonia: Lower is Not Always Better. 2012
102.	学術雑誌(原著)	Unilateral deep brain stimulation surgery in Parkinson's disease improves ipsilateral symptoms regardless of laterality. 2011/12
103.	学術雑誌(原著)	Mixed results for GPi-DBS in the treatment of cranio-facial and cranio-cervical dystonia symptoms. 2011/11
104.	学術雑誌(原著)	Steady or not following thalamic deep brain stimulation for essential tremor. 2011/09
105.	学術雑誌(原著)	Unilateral GPi-DBS as a treatment for levodopa-induced respiratory dyskinesia in Parkinson disease. 2011/09
106.	学術雑誌(原著)	Delayed clinical improvement after deep brain stimulation-related subdural hematoma. Report of 4 cases. 2011/08
107.	学術雑誌(原著)	Rescue leads: a salvage technique for selected patients with a suboptimal response to standard DBS therapy. 2011/07
108.	学術雑誌(原著)	Acute effects of bilateral subthalamic stimulation on decision-making in Parkinson's disease. 2011/03
109.	学術雑誌(原著)	Pre- and post- GPi DBS neuropsychological profiles in a case of X-linked dystonia-Parkinsonism. 2011/01
110.	学術雑誌(原著)	Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study. 2011
111.	学術雑誌(原著)	Paroxysmal Kinesigenic Dyskinesia-like Symptoms in a Patient with Tourette Syndrome. 2011
112.	学術雑誌(原著)	The Frequency of Nonmotor Symptoms among Advanced Parkinson Patients May Depend on Instrument Used for Assessment. 2011
113.	学術雑誌(原著)	Impaired in vivo dopamine release in parkin knockout mice. 2010/09/17
114.	学術雑誌(原著)	Differential response of dystonia and parkinsonism following globus pallidus internus deep brain stimulation in X-linked dystonia-parkinsonism (Lubag). 2010
115.	学術雑誌(原著)	Subsecond reward-related dopamine release in the mouse dorsal striatum. 2009/04
116.	学術雑誌(原著)	Mechanism and treatment of dropped head syndrome associated with parkinsonism. 2009/03
117.	学術雑誌(原著)	Fabrication, characterization, and application of boron-doped diamond microelectrodes for in vivo dopamine detection. 2007/11/15
118.	学術雑誌(原著)	Familial amyotrophic lateral sclerosis with rapid progression 2005/11
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■ 学会発表

1.	Real-world Programming and Sensing from Adaptive Deep Brain Stimulation for Parkinson’s Disease in Japan. （ポスター，一般） 2024/09
2.	電気生理学から考えるパーキンソン病のプラセボ効果の機序（シンポジウム・ワークショップ・パネルディスカッション等） 2023/09/09
3.	神経変性疾患における遠隔医療とデジタル技術. （シンポジウム・ワークショップ・パネルディスカッション等） 2023/06/11
4.	神経難病診療におけるICT,AIなど新技術（シンポジウム・ワークショップ・パネルディスカッション等） 2022/05/19
5.	デバイスを用いた患者モニタリング（シンポジウム・ワークショップ・パネルディスカッション等） 2019/11/06
6.	Update in device for deep brain stimulation -Experience of directional current steering- （口頭発表，特別・招待講演等） 2019/11/01
7.	パーキンソン病の新規治療戦略デバイスを用いた患者モニタリングの現状と可能性 2019/10
8.	Neuromodulation for Movement Disorders: A Case-Based Approach （シンポジウム・ワークショップ・パネルディスカッション等） 2019/09/24
9.	Complications / Troubleshooting in Patients with DBS (Dysarthria, Balance Problem, FOG, Apathy, Impulsivity, Mania, Paresthesia). （口頭発表，特別・招待講演等） 2019/08/10
10.	Optogenetics （口頭発表，特別・招待講演等） 2019/08/08
11.	ICTを用いたパーキンソン病診療の未来 2019/07
12.	3D telemedicine system for Parkinson's disease. 2019/06/11
13.	パーキンソン病における情報通信技術の応用と遠隔診療の試み（口頭発表，特別・招待講演等） 2018/11/17
14.	LCIGの使用経験期待と課題 2018/07
15.	Surgical Management of Movement Disorders. （口頭発表，特別・招待講演等） 2017/11/23
16.	Phenomenology of Movement Disorders. （口頭発表，特別・招待講演等） 2017/11/22
17.	Basics strategy to choose Device Aided Therapies （シンポジウム・ワークショップ・パネルディスカッション等） 2017/09/20
18.	Post-Surgical Management of Deep Brain Stimulation Therapies -Basic strategy to optimize motor symptom （シンポジウム・ワークショップ・パネルディスカッション等） 2017/06/06
19.	Uncommon application of DBS in movement disorders （シンポジウム・ワークショップ・パネルディスカッション等） 2016/10/28
20.	Update on Deep Brain Stimulation for Parkinson’s Disease and Other Movement Disorders. （シンポジウム・ワークショップ・パネルディスカッション等） 2016/08/04
21.	Perils and pitfalls of neuromodulation in Parkinson's disease. 2016/03/16
22.	パーキンソン病に伴う首下がりに対するリドカインの効果 2003
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■ 専門医・専門性キーワード

専門医取得の有無：有り
脳神経内科
運動障害疾患
医療デジタルトランスフォーメーション
パーキンソン病
脳深部刺激療法