■ 研究課題・受託研究・科研費
| 1. |
2005～2006
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癌抑制遺伝子p16のエピジェネティックな失活に着目した新しい分子標的予防法の開発 若手研究(B)
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| 2. |
2007～2008
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INK4ファミリー遺伝子発現誘導食品成分の探索 若手研究(B)
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| 3. |
2009～2010
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アブラナ科植物由来食品成分を用いた新規癌分子標的併用予防法の開発 若手研究(B)
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| 4. |
2011～2012
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発癌二大シグナル伝達経路を標的とした食品成分による分子標的癌予防法の開発 若手研究(B)
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| 5. |
2013～2015
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食品成分併用による発癌二大シグナル伝達経路の阻害を介した癌予防法の開発 基盤研究(C)
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| 6. |
2017～2019
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金属酸化物ナノ粒子曝露により放出されるエクソソームとその発がんリスク影響の解析 基盤研究(C) （キーワード：ナノ粒子、 酸化亜鉛、 皮膚 、分化 、金属酸化物 、産業保健）
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| 7. |
2020/04～2024/03
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ビトリゲルを介した共培養系による金属酸化物ナノ粒子経皮曝露影響の新規評価系の確立 基盤研究(C) （キーワード：酸化亜鉛ナノ粒子、分化、セネッセンス、金属酸化物、ナノ粒子）
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5件表示
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全件表示(7件)
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■ 現在の専門分野
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衛生学、公衆衛生学分野：実験系を含まない, 衛生学、公衆衛生学分野：実験系を含む, 衛生学、公衆衛生学分野：実験系を含まない, 衛生学、公衆衛生学分野：実験系を含む, 医化学
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■ 著書
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■ 学術雑誌
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1.
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学術雑誌(原著)
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Potential role of mitochondrial damage and S9 mixture including metabolic enzymes in ZnO nanoparticles-induced oxidative stress and genotoxicity in Chinese hamster lung (CHL/IU) cells. 2018/10
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2.
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学術雑誌(原著)
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Three Combined Treatments, a Novel HDAC Inhibitor OBP-801/YM753, 5-Fluorouracil, and Paclitaxel, Induce G(2) Phase Arrest Through the p38 Pathway in Human Ovarian Cancer Cells 2017
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3.
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学術雑誌(原著)
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The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL 2015/01
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4.
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学術雑誌(原著)
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Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS 2013/05
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5.
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学術雑誌(原著)
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Dehydrozingerone, a Structural Analogue of Curcumin, Induces Cell-Cycle Arrest at the G2/M Phase and Accumulates Intracellular ROS in HT-29 Human Colon Cancer Cells 2012/12
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6.
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学術雑誌(原著)
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p53 Inactivation Upregulates p73 Expression through E2F-1 Mediated Transcription 2012/08
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7.
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学術雑誌(原著)
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Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the phosphatidylinositol 3-kinase signaling pathway in human colon cancer cells 2012/03
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8.
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学術雑誌(原著)
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Polymorphisms in Promoter Sequences of the p15(INK4B) and PTEN Genes of Normal Japanese Individuals 2010/12
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9.
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学術雑誌(原著)
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Cucurbitacin B induces G(2) arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells 2010/04
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10.
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学術雑誌(原著)
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Histone Deacetylase Inhibitors and 15-Deoxy-Delta(12,14)-Prostaglandin J(2) Synergistically Induce Apoptosis 2010/04
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11.
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学術雑誌(原著)
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A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy 2009/11
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12.
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学術雑誌(原著)
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Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor 2007/11
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13.
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学術雑誌(原著)
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ZD1839 induces p15(INK4b) and causes G(1) arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway 2007/05
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14.
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学術雑誌(原著)
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Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene 2007/03
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15.
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学術雑誌(原著)
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A novel synthetic drug, LB-18, closely related to lembehyne-A derived from a marine sponge, induces caspase-independent cell death to human neuroblastoma cells 2006/07
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16.
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学術雑誌(原著)
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Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide 2006/04
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17.
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学術雑誌(原著)
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Quercetin induces gadd45 expression through a p53-independent pathway 2005/11
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18.
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学術雑誌(原著)
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Inhibitory effects of cancer cell proliferation by novel histone deacetylase inhibitors involve p21/WAF1 induction and G(2)/M arrest 2005/05
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19.
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学術雑誌(原著)
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Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway 2005/01
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20.
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学術雑誌(原著)
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Cancer prevention by antioxidants 2004
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21.
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学術雑誌(原著)
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Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A 1999/12
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22.
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学術雑誌(原著)
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TATA-binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism 1999/12
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23.
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学術雑誌(原著)
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Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120 1999/09
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24.
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学術雑誌(原著)
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TIP120B: A novel TIP120-family protein that is expressed specifically in muscle tissues 1999/08
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25.
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学術雑誌(原著)
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A serine residue in the N-terminal acidic region of rat RPB6, one of the common subunits of RNA polymerases, is exclusively phosphorylated by casein kinase II in vitro 1999/06
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26.
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学術雑誌(原著)
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Molecular cloning of a novel 120-kDa TBP-interacting protein 1996/12
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27.
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学術雑誌(原著)
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Structures of the rat proteasomal ATPases: Determination of highly conserved structural motifs and rules for their spacing 1996/03
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5件表示
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全件表示(27件)
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■ 学会発表
| 1. |
酸化亜鉛ナノ粒子曝露によるヒト皮膚角化細胞の分化誘導と細胞老化 （ポスター，一般） 2023/11/11
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■ 専門医・専門性キーワード
専門医取得の有無：無し
予防医学
分子生物学
細胞生物学
癌予防医学
遺伝子生物学
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