教員情報 - 竹下　享典 | 埼玉医科大学

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研究課題・受託研究・科研費

学術雑誌

学会発表

専門医・専門性キーワード

（最終更新日：2025-07-15 13:55:49）

  タケシタ　キョウスケ   TAKESHITA Kyosuke
  竹下　享典
   所属   埼玉医科大学医学部総合医療センター　臨床検査医学

職種教授

■ 研究課題・受託研究・科研費

1.	2007/04～2009/03	Notchシグナル制御による血管新生、再生療法の開発基盤研究(C) （キーワード：血管新生、血管内皮細胞、Notchシグナル）
2.	2007/04～2009/03	心筋梗塞後の心筋リモデリングの分子機構-カテプシンの役割及び遺伝子治療への応用基盤研究(C)
3.	2008/04～2011/03	血管再生障害からみた糖尿病性心筋症の基礎解析と新規治療法の開発基盤研究(A)
4.	2009/04～2012/03	血管病変におけるNotchシグナルの役割の解析と制御による血管病治療の開発基盤研究(C) （キーワード：分子血管病態学、動脈硬化、Notchシグナル、平滑筋、単球）
5.	2012/04～2015/03	心筋症における心筋蛋白遺伝子発現と運動耐容能評価による新規病態解明基盤研究(C) （キーワード：運動耐容能、心肺運動負荷試験、拡張型心筋症、心不全、肺高血圧症、心筋症）
6.	2013/04～2016/03	後天性von Willebrand症候群（AvWS）の動物モデルによる病態解明基盤研究(C)
7.	2013/04～2016/03	脂肪幹細胞と炎症細胞のNotchシグナル制御による肥満治療、幹細胞治療の開発基盤研究(C) （キーワード：Notchシグナル、脂肪組織、分化増殖、白色脂肪、脂肪細胞、メタボリックシンドローム、メタボリック症候群）
8.	2014/04～2017/03	外部環境ストレスによる血管系に対する影響とその作用機序の解明基盤研究(B)
9.	2014/04～2017/03	細胞外O-GlcNAc修飾のNotchシグナルと血管形成における役割基盤研究(B)
10.	2015/04～2018/03	ストレス性血管病におけるGLP1/DDP4の新しい作用メカニズム解明と治療応用基盤研究(B)
11.	2015/04～2018/03	右心不全における運動時心肺機能から導く新規心肺連関指標の開発基盤研究(C)
12.	2016/04～2019/03	慢性ストレス関連疾患の機序の解明と治療標的の探索挑戦的萌芽研究（キーワード：情動ストレス、慢性炎症、耐糖能異常、Dipeptidyl Peptidase-4、ストレス、内科）
13.	2018/04～2022/03	尿毒素によるNotchシグナルと代謝リプログラミングを介した血管障害の病態解明基盤研究(B) （キーワード：尿毒素）
14.	2020/04～2022/03	多次元臨床検査データモデルの構築と疑似ビッグデータ作成システムの開発基盤研究(C)
15.	2022/04～2025/03	白血球粒度分布分析によるCOVID-19の免疫応答ダイナミクスの解明基盤研究(C)
16.	2025/04～2028/03	リアルワールドデータを用いた薬剤起因性障害のバイオマーカーの創出基盤研究(C) （キーワード：白血球粒度分布、心電図、データウエアハウス、薬剤起因性障害）
5件表示
全件表示(16件)

■ 学術雑誌

1.	学術雑誌(原著)	Serum Produced from Expired Fresh Frozen Plasma and Cryosupernatant Supports the Proliferation of Human Cells: Cost-Effective Alternatives to Fetal Bovine Serum 2023/05
2.	学術雑誌(原著)	In Vitro Exposure to Glucose Alters the Expression of Phosphorylated Proteins in Platelets. 2023/02
3.	学術雑誌(原著)	SARS-CoV-2 RNA load and detection rate in exhaled breath condensate collected from COVID-19 patients infected with Delta variant 2022/05/17
4.	学術雑誌(原著)	Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy 2022/01/28
5.	学術雑誌(原著)	Notch1 haploinsufficiency in mice accelerates adipogenesis. 2021/08/18
6.	学術雑誌(原著)	RT-PCR diagnosis of COVID-19 from exhaled breath condensate: a clinical study. 2021/05/20
7.	学術雑誌(原著)	In vivo tracking of transplanted macrophages with near infrared fluorescent dye reveals temporal distribution and specific homing in the liver that can be perturbed by clodronate liposomes. 2020/12/01
8.	学術雑誌(原著)	A short perspective on a COVID-19 clinical study: 'diagnosis of COVID-19 by RT-PCR using exhale breath condensate samples 2020/10/01
9.	学術雑誌(総説)	Sharpening the Focus: Acupuncture Interrupts the Brain-Gut Vicious Cycle Underlying Functional Dyspepsia. 2020/10/01
10.	学術雑誌(原著)	Chronic stress augments esophageal inflammation, and alters the expression of transient receptor potential vanilloid 1 and proteaseactivated receptor 2 in a murine model. 2020/06/01
11.	学術雑誌(原著)	Indoxyl Sulfate-induced Vascular Calcification is mediated through Altered Notch Signaling Pathway in Vascular Smooth Muscle Cells. 2020/04/01
12.	学術雑誌(原著)	Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study. 2019/06
13.	学術雑誌(原著)	Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice. 2018/03
14.	学術雑誌(原著)	Anxiety and Depression among Hypertensive Outpatients in Afghanistan: A Cross-Sectional Study in Andkhoy City 2018
15.	学術雑誌(原著)	Association between Helicobacter pylori Infection and Cardiovascular Risk Factors among Patients in the Northern Part of Afghanistan: a Cross-Sectional Study in Andkhoy City 2018
16.	学術雑誌(原著)	Corrigendum to"The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy"[J. Cardiol. 71 (2018) 284-290] 2018
17.	学術雑誌(原著)	Left ventricular hypertrophy and proteinuria in patients with essential hypertension in Andkhoy, Afghanistan 2018
18.	学術雑誌(原著)	Measurements of renal shear wave velocities in chronic kidney disease patients 2018
19.	学術雑誌(原著)	The Selvester QRS score as a predictor of cardiac events in nonischemic dilated cardiomyopathy 2018
20.	学術雑誌(原著)	Abnormal Circadian Blood Pressure Profile as a Prognostic Marker in Patients with Nonischemic Dilated Cardiomyopathy 2017
21.	学術雑誌(原著)	Assessment of left ventricular diastolic function during trastuzumab treatment in patients with HER2-positive breast cancer 2017
22.	学術雑誌(原著)	Biphasic Force-Frequency Relation Predicts Primary Cardiac Events in Patients With Hypertrophic Cardiomyopathy 2017
23.	学術雑誌(原著)	Circulatory power and ventilatory power over time under goal-oriented sequential combination therapy for pulmonary arterial hypertension 2017
24.	学術雑誌(原著)	Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress 2017
25.	学術雑誌(原著)	Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress 2017
26.	学術雑誌(原著)	Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells 2017
27.	学術雑誌(原著)	Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency 2017
28.	学術雑誌(原著)	Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice 2017
29.	学術雑誌(原著)	Myocardial contractile reserve predicts left ventricular reverse remodeling and cardiac events in dilated cardiomyopathy 2017
30.	学術雑誌(原著)	O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals 2017
31.	学術雑誌(原著)	Sokolow-Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy 2017
32.	学術雑誌(原著)	Urinary and circulating levels of the anti-angiogenic isoform of vascular endothelial growth factor-A in patients with chronic kidney disease 2017
33.	学術雑誌(原著)	Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice 2017
34.	学術雑誌(原著)	Angiotensin receptor blocker improves a stress-induced prothrombotic state in a murine model 2016
35.	学術雑誌(原著)	Associations between proteinuria and cardiovascular risk factors among hypertensive patients in Andkhoy, Afghanistan 2016
36.	学術雑誌(原著)	Cardiopulmonary Exercise Testing as a Tool for Diagnosing Pulmonary Hypertension in Patients with Dilated Cardiomyopathy 2016
37.	学術雑誌(原著)	Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway 2016
38.	学術雑誌(原著)	Dipeptidyl peptidase- IV inhibitor alogliptin improves stress-induced insulin resistance and prothrombotic state in a murine model 2016
39.	学術雑誌(原著)	Effects of bosentan on peripheral endothelial function in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension 2016
40.	学術雑誌(原著)	Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions 2016
41.	学術雑誌(原著)	Identification of a novel missense mutation (563G>a) in the ABO gene associated with a Bel phenotype 2016
42.	学術雑誌(原著)	Asymptomatic left atrial thrombus in a dialysis-dependent patient free of thrombogenic abnormalities 2015
43.	学術雑誌(原著)	Cathepsin S activity controls ischemia-induced neovascularization in mice 2015
44.	学術雑誌(原著)	Impact of Admission Anemia on Coronary Microcirculation and Clinical Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention 2015
45.	学術雑誌(原著)	Impact of airflow limitation on carotid atherosclerosis in coronary artery disease patients 2015
46.	学術雑誌(原著)	Impact of low-grade albuminuria on left ventricular diastolic dysfunction 2015
47.	学術雑誌(原著)	Angiotensin II receptor blocker ameliorates stress-induced adipose tissue inflammation and insulin resistance 2014
48.	学術雑誌(原著)	Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men 2014
49.	学術雑誌(原著)	Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: an endothelin receptor antagonist improves the peak PETCO2 2014
50.	学術雑誌(原著)	Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia 2014
51.	学術雑誌(原著)	Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions 2014
52.	学術雑誌(原著)	Does angiotensin receptor blockade ameliorate the prothrombotic tendency in hypertensive patients with atrial fibrillation? Breaking the vicious cycle 2014
53.	学術雑誌(原著)	Efficacy and safety of radiofrequency catheter ablation for atrial fibrillation in chronic hemodialysis patients 2014
54.	学術雑誌(原著)	Impact of serum bilirubin levels on carotid atherosclerosis in patients with coronary artery disease 2014
55.	学術雑誌(原著)	Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells 2014
56.	学術雑誌(原著)	Plasma indoxyl sulfate and estimated glomerular filtration rate 2014
57.	学術雑誌(原著)	Plasminogen activator inhibitor-1 in aging 2014
58.	学術雑誌(原著)	Possible involvement of Notch signaling in the pathogenesis of Buerger's disease 2014
59.	学術雑誌(原著)	Prognostic impact of combined late gadolinium enhancement on cardiovascular magnetic resonance and peak oxygen consumption in ambulatory patients with nonischemic dilated cardiomyopathy 2014
60.	学術雑誌(原著)	Recovery of flow-mediated vasodilatation after repetitive measurements is involved in early vascular impairment: comparison with indices of vascular tone 2014
61.	学術雑誌(原著)	Renin inhibition reduces atherosclerotic plaque neovessel formation and regresses advanced atherosclerotic plaques 2014
62.	学術雑誌(原著)	[Assessment of cardiac contractile reserve] 2013
63.	学術雑誌(原著)	Association between cardiopulmonary exercise and dobutamine stress testing in ambulatory patients with idiopathic dilated cardiomyopathy: a comparison with peak VO(2) and VE/VCO(2) slope 2013
64.	学術雑誌(原著)	Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy 2013
65.	学術雑誌(原著)	Association of cardiorespiratory fitness with characteristics of coronary plaque: assessment using integrated backscatter intravascular ultrasound and optical coherence tomography 2013
66.	学術雑誌(原著)	Indoxyl sulfate, a uremic toxin, and carotid intima-media thickness in patients with coronary artery disease 2013
67.	学術雑誌(原著)	Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker 2013
68.	学術雑誌(原著)	Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction 2013
69.	学術雑誌(原著)	Relationship of myocardial fibrosis to left ventricular and mitochondrial function in nonischemic dilated cardiomyopathy--a comparison of focal and interstitial fibrosis 2013
70.	学術雑誌(原著)	Usefulness of serum cardiac troponins T and I to predict cardiac molecular changes and cardiac damagein patients with hypertrophic cardiomyopathy 2013
71.	学術雑誌(原著)	Carotidynia with carotid arterial thrombosis 2012
72.	学術雑誌(原著)	Impact of metabolic syndrome on various aspects of microcirculation and major adverse cardiac events in patients with ST-segment elevation myocardial infarction 2012
73.	学術雑誌(原著)	Impact of plaque burden in the left main coronary artery determined by intravascular ultrasound on cardiovascular events in a Japanese population undergoing percutaneous coronary intervention 2012
74.	学術雑誌(原著)	Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib 2012
75.	学術雑誌(原著)	Predictive value of heart rate recovery after exercise testing in addition to brain natriuretic peptide levels in ambulatory patients with nonischemic dilated cardiomyopathy 2012
76.	学術雑誌(原著)	Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1 2012
77.	学術雑誌(原著)	Ankle brachial pressure index but not brachial-ankle pulse wave velocity is a strong predictor of systemic atherosclerotic morbidity and mortality in patients on maintenance hemodialysis 2011
78.	学術雑誌(原著)	Circulating omentin is associated with coronary artery disease in men 2011
79.	学術雑誌(原著)	Coincidental finding of isolated congenital double-orifice mitral valve in two adult patients 2011
80.	学術雑誌(原著)	Impact of the low- to high-density lipoprotein cholesterol ratio on composition of angiographically ambiguous left main coronary artery plaque 2011
81.	学術雑誌(原著)	Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin 2011
82.	学術雑誌(原著)	Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF 2011
83.	学術雑誌(原著)	Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction 2011
84.	学術雑誌(原著)	Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats 2010
85.	学術雑誌(原著)	Impact of acarbose on carotid intima-media thickness in patients with newly diagnosed impaired glucose tolerance or mild type 2 diabetes mellitus: A one-year, prospective, randomized, open-label, parallel-group study in Japanese adults with established coronary artery disease 2010
86.	学術雑誌(原著)	Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice 2010
87.	学術雑誌(原著)	A novel cholesterol absorption inhibitor, ezetimibe, decreases adipose-derived and vascular PAI-1 expression in vivo 2009
88.	学術雑誌(原著)	gamma-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice 2009
89.	学術雑誌(原著)	Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers 2009
90.	学術雑誌(原著)	Smooth muscle Notch1 mediates neointimal formation after vascular injury 2009
91.	学術雑誌(原著)	Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo 2009
92.	学術雑誌(原著)	Critical role of endothelial Notch1 signaling in postnatal angiogenesis 2007
93.	学術雑誌(原著)	Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen 2007
94.	学術雑誌(原著)	Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice 2007
95.	学術雑誌(原著)	Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt 2006
96.	学術雑誌(原著)	Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice 2006
97.	学術雑誌(原著)	Requirement of Rac1 in the development of cardiac hypertrophy 2006
98.	学術雑誌(原著)	Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly 2005
99.	学術雑誌(原著)	Essential role of endothelial Notch1 in angiogenesis 2005
100.	学術雑誌(原著)	Diagnostic usefulness of postexercise systolic blood pressure response for detection of coronary artery disease in patients with echocardiographic left ventricular hypertrophy 2004
101.	学術雑誌(原著)	Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction 2004
102.	学術雑誌(原著)	Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression 2004
103.	学術雑誌(原著)	Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers 2004
104.	学術雑誌(原著)	Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice 2004
105.	学術雑誌(原著)	Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibodyproduced by the DNA vaccine method 2003
106.	学術雑誌(原著)	Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese: Factor VII polymorphism and coronary disease 2002
107.	学術雑誌(原著)	Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging,"Klotho"mouse 2002
108.	学術雑誌(原著)	Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals 2002
109.	学術雑誌(原著)	The effects of vasodilators on the relaxation of guinea-pig aorta during acute recoil 2002
5件表示
全件表示(109件)

■ 学会発表

1.	「慢性ストレスが代謝疾患に与える影響：DPP4/GLP-1およびAPN/CTSK軸に焦点を当てて」座長（口頭発表） 2025/03/30
2.	「コバス t 711 の使用経験およびISO 15189の考察」座長（口頭発表） 2025/02/08
3.	「ナノピアTARC」導入のための基礎検討と採血管の影響について（口頭発表，一般） 2024/12/08
4.	尿沈渣検査から診断に至った女児のファブリー病（口頭発表，一般） 2024/12/08
5.	Th2 ケモカイン・TARC キット「ナノピア TARC」の相関性の検討（口頭発表，一般） 2024/11/30
6.	動線分析を利用した新しい検査室へ向けての検討（口頭発表，一般） 2024/11/30
7.	新規検査項目「Emit カフェイン」の基礎検討（口頭発表，一般） 2024/10/06
8.	アトピー性皮膚炎の重症度評価の補助に用いるTARC測定試薬の妥当性確認の検討（口頭発表，一般） 2024/10/05
9.	乳がん治療後に発症した骨髄肉腫（Myeloid sarcoma）の 1 症例（口頭発表，一般） 2024/07/21
10.	胆道閉鎖症術前腹部超音波検査による胆嚢収縮評価の有用性（口頭発表，一般） 2024/06/01
11.	「コバス t 711 の使用経験およびISO 15189の考察」座長（口頭発表） 2024/02/08
12.	生理機能検査室における外来・病棟心電図管理の改善に向けた取り組み（口頭発表，一般） 2023/12/03
13.	肺癌に対するがん遺伝子パネル検査により偶然診断できた本態性血小板血症（口頭発表，一般） 2023/12/03
14.	著明な出血傾向を呈し、凝固Ⅴ、X因子欠乏を認めたアミロイドーシスの1例（口頭発表，一般） 2023/12/03
15.	頚部に発生した異所性胸腺腫の1例（口頭発表，一般） 2023/12/03
16.	髄液一般検査における FilmArray 髄膜炎・脳炎パネルの検査状況と症例検討（口頭発表，一般） 2023/12/03
17.	ラジオメーター社　クオリティマネージャーの有用性について（口頭発表，一般） 2023/11/18
18.	新規検査項目「Emit カフェイン」の基礎的検討（口頭発表，一般） 2023/11/18
19.	Pasteurella multocida による細菌性髄膜炎を引き起こした新生児の一症例（口頭発表，一般） 2023/11/17
20.	若年性脳梗塞の原因検索に施行した頸部血管エコーで同定できた Bow hunter 症候群の1例（口頭発表，一般） 2023/05/27
21.	ギリアデル・アレルギーが原因の好酸球性髄膜炎の後、胸膜転移した膠芽腫の1症例（口頭発表，一般） 2023/05/21
22.	尿沈渣検査に形質細胞を認めた多発性骨髄腫の髄外病変の1症例（口頭発表，一般） 2023/05/21
23.	糖鎖欠損トランスフェリン（CDT）測定と飲酒患者との関係性について（口頭発表，一般） 2023/05/21
24.	Capnopcytophaga canimorsus による敗血症で好中球に細菌貪食像を認めた1症例（口頭発表，一般） 2023/05/20
25.	抗癌剤治療中電解質異常により Tdp 様 VT の心電図波形を呈しスタットコールを行った症例（口頭発表，一般） 2023/05/20
26.	18SｒＲＮＡ遺伝子とCOX1遺伝子によるStrongyloides　stercoralisの同定（ポスター，一般） 2020/12/09
5件表示
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■ 専門医・専門性キーワード

専門医取得の有無：有り
日本内科学会総合内科専門医　指導医
日本循環器学会認定循環器専門医　関東甲信越支部評議員
日本医師会認定産業医
Fellow of American Heart Association
日本臨床検査医学会専門医