イノウエ イクオ   INOUE Ikuo
  井上 郁夫
   所属   埼玉医科大学  医学部 教職員・学生健康推進センター
   職種   教授
論文種別 学術雑誌(原著)
言語種別 英語
査読の有無 査読あり
招待の有無 招待あり
表題 Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle.
掲載誌名 正式名:Developmental biology
略  称:Dev Biol
ISSNコード:1095564X00121606
掲載区分国外
巻・号・頁 1-10頁
著者・共著者 Nakano Takanari, Aochi Hidekazu, Hirasaki Masataka, Takenaka Yasuhiro, Fujita Koji, Tamura Masaru, Soma Hiroaki, Kamezawa Hajime, Koizumi Takahiro, Shibuya Hirotoshi, Inomata Reiko, Okuda Akihiko, Murakoshi Takayuki, Shimada Akira,◎ Inoue Ikuo
発行年月 2021/07/09
概要 PPARγ1 is highly expressed in the late-stage placenta, but its role is unknown yet.
Pparγ1−/− conceptuses produced mature placentas with impaired vascularization.
This was due to the loss of PPARγ1 in sinusoidal trophoblast giant cells (TGCs).
The nuclei of the Pparγ1−/− TGCs were huge with excess endocycling.
PPARγ1 may coordinate to exit endocycling and allow the terminal differentiation.
DOI 10.1016/j.ydbio.2021.07.003
PMID 34246625