イノウエ　イクオ   INOUE Ikuo   井上　郁夫    所属   埼玉医科大学  医学部 教職員・学生健康推進センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Evolocumab vs. Ezetimibe in Statin-Intolerant Hyperlipidemic Japanese Patients: Phase 3 GAUSS-4 Trial.
掲載誌名	正式名：Journal of atherosclerosis and thrombosis 略　 称：J Atheroscler Thromb
掲載区分	国外
巻・号・頁	27(5),471-484頁
著者・共著者	Koba Shinji, Inoue Ikuo, Cyrille Marcoli, Lu Chen, Inomata Hyoe, Shimauchi Junichiro, Kajinami Kouji
発行年月	2020/05/01
概要	AIM:In patients with hyperlipidemia, intolerance to statins presents a challenge in reducing the risk of events associated with cardiovascular disease. This phase 3, randomized, double-blind trial in Japanese patients with statin intolerance aimed to evaluate the efficacy and safety of evolocumab vs. ezetimibe in lowering low-density lipoprotein-cholesterol (LDL-C).RESULTS:Sixty-one patients were randomized to evolocumab (n=40) or ezetimibe (n=21). For the co-primary endpoints of percent change from the baseline in mean LDL-C to the mean of weeks 10 and 12 and to week 12, the evolocumab-ezetimibe treatment differences were -39.4% (95% CI, -47.2% to -31.5%) and -40.1% (95% CI, -48.7% to -31.6%), respectively (adjusted p＜0.0001).
DOI	10.5551/jat.50963
PMID	31748467