イノウエ　イクオ   INOUE Ikuo   井上　郁夫    所属   埼玉医科大学  医学部 教職員・学生健康推進センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
掲載誌名	正式名：The Journal of clinical investigation 略　 称：J Clin Invest
掲載区分	国外
巻・号・頁	89(2),706-11頁
著者・共著者	Yamada N, Inoue I, Kawamura M, Harada K, Watanabe Y, Shimano H, Gotoda T, Shimada M, Kohzaki K, Tsukada T
発行年月	1992/02
概要	Apo E plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface LDL receptor. We isolated apo E from plasma of 1% cholesterol-fed rabbits and administered 10 mg of purified apo E intravenously into five Watanabe heritable hyperlipidemic rabbits three times a week from their age of 2.5 months to 11 months for 8.5 months. After sustained administration to apo E, we found a significant reduction in the accumulation of cholesterol ester in aortae (1.55 +/- 0.07 mg/g tissue) as compared to control rabbits (4.32 +/- 0.61 mg/g tissue). Supporting this, the percentage of the surface area of the aorta with macroscopic plaque was remarkably decreased in apo E-treated animals (18.8 +/- 5.1% vs. 38.8 +/- 8.0% in control). Thus, apo E definitely prevented the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
DOI	10.1172/JCI115639
PMID	1737858