イノウエ　イクオ   INOUE Ikuo   井上　郁夫    所属   埼玉医科大学  医学部 教職員・学生健康推進センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy.
掲載誌名	正式名：NPJ aging and mechanisms of disease 略　 称：NPJ Aging Mech Dis
掲載区分	国外
巻・号・頁	4,7頁
著者・共著者	Ikegami Yuichi, , Inoue Ikuo, Inoue Kaiji, Shinoda Yuichi, Iida Shinichiro, Goto Seiichi, Nakano Takanari, Shimada Akira, Noda Mistuhiko
発行年月	2018/04
概要	Statins and/or PCSK9 inhibitors cause the regression of coronary atheroma and reduce clinical events. However, it currently remains unclear whether these drugs modulate coronary atheroma calcification in vivo. Coronary artery calcium (CAC) scores (Agatston Units, AUs) were estimated in 120 patients receiving coronary computed tomographic angiography (CCTA) (63% males; median age 56 years). The CAC scores were compared among the three groups: (1) neither statin nor PCSK9 inhibitor therapy, (2) statin monotherapy, and (3) statin and PCSK9 inhibitor combination therapy in an unpaired cross-sectional study.
DOI	10.1038/s41514-018-0026-2
PMID	29951223