スズキ　オキヒデ   SUZUKI Okihide   鈴木　興秀    所属   埼玉医科大学  医学部 総合医療センター　ゲノム診療科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.
掲載誌名	正式名：Surgery today 略　 称：Surg Today
掲載区分	国外
巻・号・頁	47(9),1135-1146頁
著者・共著者	Suzuki Okihide, Eguchi Hidetaka, Chika Noriyasu, Sakimoto Takehiko, Ishibashi Keiichiro, Kumamoto Kensuke, Tamaru Jun-Ichi, Tachikawa Tetsuhiko, Akagi Kiwamu, Arai Tomio, Okazaki Yasushi, Ishida Hideyuki
発行年月	2017/09
概要	PURPOSE:To clarify the prevalence and clinicopathologic/molecular characteristics of mismatch repair (MMR)-deficient colorectal cancer in the young Japanese population.METHODS:Immunohistochemical analyses for MMR proteins (MLH1, MSH2, MSH6, and PMS2) were performed in formalin-fixed paraffin-embedded sections prepared from the resected CRC specimens of 119 consecutive patients aged<50 years old, who underwent resection of the primary tumor at our institution between 1996 and 2015. Analyses for somatic BRAF V600E mutation, somatic hypermethylation of the MLH1 promoter, and germline MMR gene mutations were undertaken where indicated.RESULTS:MMR protein loss was found in 10 patients (8.4%), 7 (5.9%) of whom were subsequently identified to have Lynch syndrome (LS). The remaining 3 patients were categorized as having sporadic MMR-deficient CRC (n = 2) or"possible LS (n = 1)". In multivariate logistic regression analysis, the presence of tumor-infiltrating lymphocytes///
DOI	10.1007/s00595-017-1486-x
PMID	28258479