コタニ　ノリヒロ   KOTANI Norihiro   小谷　典弘    所属   埼玉医科大学  医学部 医学研究センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Luminal plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine.
掲載誌名	正式名：Journal of clinical biochemistry and nutrition 略　 称：J Clin Biochem Nutr
掲載区分	国外
巻・号・頁	63(2),102-105頁
著者・共著者	Nakano Takanari, Inoue Ikuo, Takenaka Yasuhiro, Ikegami Yuichi, Kotani Norihiro, Shimada Akira, Noda Mitsuhiko, Murakoshi Takayuki
発行年月	2018/09
概要	Plant sterols are used as food additives to reduce intestinal cholesterol absorption. They also increase fecal neutral sterol (FNS) excretion irrespective of the absorption inhibition. Intestine-mediated reverse cholesterol transport, or trans-intestinal cholesterol efflux (TICE), provides the major part of the increase of FNS excretion. However, it is unknown whether plant sterols stimulate TICE or not. We have shown previously that TICE can be evaluated by brush border membrane (BBM)-to-lumen cholesterol efflux. Thus, we examined whether luminal plant sterols stimulate BBM-to-lumen cholesterol efflux in the intestinal tract or not in mice. Cannulated upper jejunum that had been pre-labeled with orally given3
DOI	10.3164/jcbn.17-116
PMID	30279620