タジマ　ヒロユキ   TAJIMA Hiroyuki   田島　廣之    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   特任教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Comparative Study of Transcatheter Renal Arterial Embolization with and without Closed Renal Circuit: Pharmacokinetic and Histologic Assessment in Pigs
掲載誌名	正式名：RADIOLOGY ISSNコード：00338419
出版社	RADIOLOGICAL SOC NORTH AMERICA
巻・号・頁	250(3),714-720頁
著者・共著者	Shiro Onozawa,Satoru Murata,Akira Shimizu,Hiroyuki Tajima,Fumitaka Hidaka,Shin-ichiro Kumita,Kazuhiro Nomura
発行年月	2009/03
概要	Purpose: To assess the degree of renal necrosis and the leakage of absolute ethanol by using two methods: transcatheter renal artery embolization (TAE) and TAE performed with a closed renal circuit (CRC) (TAE/CRC), both performed by using ethanol and iodized oil, in a pig model.Materials and Methods: All animal experiments were conducted in accordance with our university guidelines for animal care and experimentation. Fourteen pigs were classified in two groups: standard TAE and TAE/CRC groups. In the TAE/CRC group, the renal artery and vein were occluded with balloon catheters; in the TAE group, only the renal artery was occluded. An emulsion of absolute ethanol (0.5 mL per kilogram of body weight) and iodized oil (emulsion ratio, 4: 1) was injected in the renal artery in both groups. In the TAE/CRC group, we aspirated the blood containing the emulsion via the renal vein during arterial infusion. We measured the ethanol concentrations of the systemic circulation. Four days after embolization, the kidneys in both groups were removed and histopathologic examination was performed and results were compared.Results: The mean systemic ethanol concentration was less than 0.1 mg/mL in t
DOI	10.1148/radiol.2503080215