タジマ　ヒロユキ   TAJIMA Hiroyuki   田島　廣之    所属   埼玉医科大学  医学部 国際医療センター　放射線科（放射線腫瘍科、画像診断、核医学科）    職種   特任教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Pilot study of transcatheter arterial ethanol embolization under closed renal circuit for large renal cell carcinomas
掲載誌名	正式名：EUROPEAN RADIOLOGY ISSNコード：09387994
出版社	SPRINGER
巻・号・頁	18(7),1464-1472頁
著者・共著者	Satoru Murata,Hiroyuki Tajima,Shiro Onozawa,Shinichiro Kumita,Yukihiro Kondo,Kazuhiro Nomura
発行年月	2008/07
概要	The safety of a new technique, designated"transcatheter arterial embolization (TAE) with aspiration via a balloon-occluded renal drainage vein"(TAE-ABOD), for the management of large renal cell carcinomas (RCCs). The subjects were 25 patients with RCC who underwent a total of 27 sessions of TAE-ABOD. This TAE-ABOD technique incorporates two procedures: balloon occlusion of renal drainage vein and infusion of absolute ethanol into the tumor-feeding arteries during aspiration of blood via a balloon catheter, thereby reducing leakage of absolute ethanol into the systemic circulation. Our primary endpoint was to establish a safe regimen for high-dose ethanol injection therapy, and our secondary endpoint was to assess global survival of the patients. The administered dose of ethanol ranged from 0.2 to 0.5 ml/kg [median: 0.34 (SD: 0.10) ml/kg], increased in a stepwise manner. The systemic ethanol concentration was measurable in 14 patients, and was less than 0.1 mg/ml in 12 and from 0.1 to less than 0.2 mg/ml in two. There were no major complications such as renal failure or renal abscess. TAE-ABOD can safely deliver a high dose of absolute ethanol for the treatment of large RCCs.
DOI	10.1007/s00330-008-0895-z