オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain
掲載誌名	正式名：JOURNAL OF ANESTHESIA ISSNコード：09138668
出版社	SPRINGER TOKYO
巻・号・頁	22(4),449-452頁
著者・共著者	Naomi Ito,Shigeru Saito,Makiko Hardy Yamada,Shiro Koizuka,Hideaki Obata,Koichi Nishikawa,Yasuhiko Tabata
発行年月	2008/11
概要	Severe ischemic pain is difficult to treat with a single therapy. Although modern angiogenic therapies have been used in patients with peripheral arterial occlusive diseases, a regimen combining novel angiogenic therapy and classic nerve blocks, including sympathectomy, has not been discussed to date. In this case report, we present two patients with peripheral arterial occlusive disease who were first treated with medication and lumbar sympathectomy, and then with a novel gelatin hydrogel drug-delivery system loaded with basic fibroblast growth factor. The gelatin hydrogel combined with recombinant basic fibroblast growth factor was injected intramuscularly into the ischemic limbs. In the first patient, with arteriosclerosis obliterans, a foot ulcer was healed, and the original score for resting pain (visual analogue scale, 5/10) was decreased to 0/10. In the second patient, with Buerger's disease, a large toe ulcer was healed, and his resting pain (visual analogue scale, 8/10) was decreased to 1/10. Some other parameters, such as skin surface temperature, transcutaneous oxygen partial pressure, and pain-free walking distance,were also improved in both patients after the com
DOI	10.1007/s00540-008-0649-8
PMID	19011787