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オバタ ヒデアキ
OBATA Hideaki
小幡 英章 所属 埼玉医科大学 医学部 総合医療センター 麻酔科（麻酔科、産科麻酔科） 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain |
| 掲載誌名 | 正式名：Anesthesia and Analgesia ISSNコード：00032999 |
| 巻・号・頁 | 100(5),1406-1410頁 |
| 著者・共著者 | Hideaki Obata,Shigeru Saito,Shiro Koizuka,Koichi Nishikawa,Fumio Goto |
| 発行年月 | 2005/05 |
| 概要 | Antidepressants are often used to treat neuropathic pain. In the present study, we determined the antiallodynic effects of selective monoamine reuptake inhibitors in the spinal cord in a rat model of neuropathic pain. Mechanical allodynia was produced by tight ligation of the left L5 and L6 spinal nerves and determined by applying von Frey filaments to the left hindpaw. A serotonin noradrenaline reuptake inhibitor, milnacipran, a selective serotonin reuptake inhibitor, paroxetine, or a selective noradrenaline reuptake inhibitor, maprotiline, was administered intrathecally via a chronically implanted catheter. Milnacipran produced dose-dependent antiallodynic effects at doses between 3 μg and 100 μg. The effect lasted for 7 h after injection of 100 μg (P< 0.05). The antiallodynic effect of 30 μg of milnacipran was attenuated by intrathecal coadministration of 30 μg of yohimbine, an α2-adrenoceptor antagonist, 30 μg of methysergide, a serotonin receptor antagonist, or 30 μg of atropine, a muscarinic receptor antagonist (P< 0.01, respectively). Intraperitoneal administration of milnacipran had no antiallodynic effects at doses of 3 to 30 mg/kg. Antiallodynic effects we |
| DOI | 10.1213/01.ANE.0000149546.97299.A2 |
| PMID | 15845695 |