オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats
掲載誌名	正式名：PAIN ISSNコード：03043959
出版社	ELSEVIER SCIENCE BV
巻・号・頁	113(3),271-276頁
著者・共著者	H Obata,D Conklin,JC Eisenach
発行年月	2005/02
概要	Spinal noradrenaline (NA) released in response to noxious stimuli may play an important role in suppression of nociceptive transmission. Here, we investigated the efficacy of a competitive NA transporter inhibitor (reboxetine) and a noncompetitive NA transporter inhibitor peptide, Xen2174. isolated from the Pacific cone snail, to treat tactile hypersensitivity following paw incisional surgery. Male Sprague-Dawley rats were anesthetized, an incision of the plantar aspect of the hind paw was performed, and withdrawal threshold to von Frey filaments near the surgical site determined. Reboxetine (0.5-5 mug) and Xen2174 (0.3-100 mug) increased withdrawal threshold when injected 24 h after paw incision, with a peak effect at 15-60 min, for Xen2174, an ED50 value of 0.64 mug. Administration of Xen2174 (3-30 mug) 15 min before incision also reduced hypersensitivity in a dose-dependent manner. Withdrawal threshold after the single 30 mug dose was greater than vehicle control even at 2, 3, and 5 days after incision. Doses less than or equal to30 mug did not alter spontaneous behavior. The antihypersensitivity effect of 10 mug of Xen2174 was totally blocked by the alpha2-adrenoceptor antagoni
DOI	10.1016/j.pain.2004.10.017
PMID	15661433