オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Possible involvement of a muscarinic receptor in the anti-allodynic action of a 5-HT2 receptor agonist in rats with nerve ligation injury
掲載誌名	正式名：BRAIN RESEARCH ISSNコード：00068993
出版社	ELSEVIER SCIENCE BV
巻・号・頁	932(1-2),124-128頁
著者・共著者	H Obata,S Saito,M Sasaki,F Goto
発行年月	2002/04
概要	Intrathecal administration of 5-HT2 receptor agonists produces an anti-allodynic effect in a rat model of neuropathic pain. Several non-serotonergic neurotransmitters have been implicated these anti-nociceptive effects. In the present study, intrathecal pre-treatment with the muscarinic receptor antagonist atropine (10 and 30 mug) and pirenzepine (10 mug) reversed the anti-allodynic effect of the 5-HT2 receptor agonist alpha-methyl-5-hydroxytryptamine, unlike various other antagonists, Thus, muscarine receptors may be involved in the anti-allodynic action of intrathecally injected 5-HT2 receptor agonist. (C) 2002 Elsevier Science B.V. All rights reserved.
PMID	11911869