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オバタ ヒデアキ
OBATA Hideaki
小幡 英章 所属 埼玉医科大学 医学部 総合医療センター 麻酔科（麻酔科、産科麻酔科） 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Reduction of cerebral hyperemia with antihypertensive medication after electroconvulsive therapy |
| 掲載誌名 | 正式名：CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE ISSNコード：0832610X |
| 出版社 | CANADIAN ANAESTHETISTS SOC INC |
| 巻・号・頁 | 47(8),767-774頁 |
| 著者・共著者 | S Saito,Y Kadoi,N Iriuchijima,H Obata,K Arai,T Morita,F Goto |
| 発行年月 | 2000/08 |
| 概要 | Purpose: Several different anti-hypertensive regimens have been introduced for the prevention of systemic hyperdynamic responses after electrically induced seizures. In the present study, the effects of anti-hypertensive medications on cerebral circulation were studied.Methods: Systemic blood pressure was controlled by several anti-hypertensive medications, nicardipine, prostaglandin E1, alprenolol and nitroglycerin, in 30 patients (150 electroconvulsive therapy trials). Changes in cerebral blood flow velocity were measured by transcranial Doppler sonography of the right middle cerebral artery from the start of anesthesia to 10 min afterthe electrical shock.Results: Administration of a Ca2+ antagonist, nicardipine, or prostaglandin E1 did not alter the augmented cerebral blood flow velocity after the seizure. However,a beta-adrenergic blocking agent, alprenolol (P< 0.05) or nitroglycerin (P< 0.01) partially inhibited the increase in cerebral blood flow velocity. Maximal blood flow velocity was 133% larger than the pre-anesthesia value in the control group, 109% in the nicardipine group, 113% in the prostaglandin E1 group, 72% in the alprenolol group, and 45% in the nitro |
| PMID | 10958093 |