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オバタ ヒデアキ
OBATA Hideaki
小幡 英章 所属 埼玉医科大学 医学部 総合医療センター 麻酔科（麻酔科、産科麻酔科） 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Intrathecal co-administration of NMDA antagonist and NK-1 antagonist reduces MAC of isoflurane in rats |
| 掲載誌名 | 正式名：ACTA ANAESTHESIOLOGICA SCANDINAVICA ISSNコード：00015172 |
| 出版社 | MUNKSGAARD INT PUBL LTD |
| 巻・号・頁 | 43(7),753-759頁 |
| 著者・共著者 | K Ishizaki,M Sasaki,S Karasawa,H Obata,T Nara,F Goto |
| 発行年月 | 1999/08 |
| 概要 | Background: Intravenous administration of N-methyl-D-aspartate (NMDA) receptor antagonists and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonists reportedly reduce the minimum alveolar anaesthetic concentration (MAC) for inhalation anaesthetics. If pain perception can be prevented by the intrathecal administration of antinociceptive receptor antagonists, these agents may reduce the requirements for inhalation anaesthetics. We studied the effect of intrathecal administration of an AMPA/kainate receptor antagonist, a metabotropic glutamate (mGlu) receptor antagonist and coadministration of NMDA and a neurokinin-1(NK-1) receptor antagonist drugs at low doses on the MAC.Methods: After Wistar rats (n=36) were fitted with indwelling intrathecal catheters, the MAC of isoflurane was determined following intrathecal administration of a non-NMDA receptor antagonist (CNQX) at 10 mu g, a mGlu receptor antagonist (AP3) at 10 mu g, or a combination of NMDA receptor antagonist (APV) at 0.01 mu g to 1 mu g with NK-1 receptor antagonist (CP96345, CP) at 0.1 mu g to 10 mu g. Subsequently, a reversal dose of intrathecal NMDA with substance P (SP) was administered, |
| PMID | 10456816 |