テルイ　ヤスヒト   TERUI Yasuhito   照井　康仁    所属   埼玉医科大学  医学部 血液内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Incidence and risk factors for febrile neutropenia in Japanese patients with non-Hodgkin B cell lymphoma receiving R-CHOP: 2-year experience in a single center (STOP FN in NHL 2)
掲載誌名	正式名：Support Care Cancer ISSNコード：14337339
掲載区分	国外
巻・号・頁	28,571-579頁
著者・共著者	Yokoyama, M., Kusano, Y., Nishihara, A., Inoue, N., Nishimura, N., Mishima, Y., Terui, Y., Nukada, T., Nomura, T., Hatake, K.
発行年月	2020
概要	Data on Japanese patients were lacking; thus, we previously determined the incidence of FN in B-NHL patients at our center. Here, we aimed to gain additional insights into pegfilgrastim use in this population.|This single-center, retrospective, observational study (STOP FN in NHL 2) enrolled patients with B-NHL who underwent a regimen comprising rituximab and CHOP therapy over a 2-year period. The incidence of FN in cycle 1 of chemotherapy, risk factors for FN development, and use of daily G-CSF and pegfilgrastim were evaluated.|We evaluated 239 patients: 61 patients did not receive G-CSF and 178 received G-CSF. The incidence of FN was 10.5% in cycle 1 and 13.0% in all cycles. The FN incidence was significantly lower in patients receiving daily G-CSF and pegfilgrastim than patients not receiving G-CSF. Significant risk factors for FN were age ≥ 65 years, albumin < 3.5 g/dL, hemoglobin < 12 g/dL, and no prophylaxis with daily G-CSF/pegfilgrastim during cycle 1.
DOI	10.1007/s00520-019-04802-4
文献番号	31093770