テルイ　ヤスヒト   TERUI Yasuhito   照井　康仁    所属   埼玉医科大学  医学部 血液内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	MYD88 L265P mutation detected by digital PCR as a prognostic factor in patients with diffuse large B-cell lymphoma in rituximab era
掲載誌名	正式名：Leuk Res ISSNコード：18735835
掲載区分	国外
巻・号・頁	97,106426頁
著者・共著者	Nishimura, N., Takeuchi, K., Asaka, R., Tuyama, N., Inoue, N., Kusano, Y., Mishima, Y., Yokoyama, M., Terui, Y.
発行年月	2020
概要	To test if the presence of the MYD88 L265P mutation is a prognostic factor for secondary CNS relapse, we carried out the digital PCR analysis of 134 samples from patients with DLBCL at diagnosis. The MYD88 L265P mutations were detected in 22 (16.4%) patients, particularly in those with a non-GC subtype, CD5-positive, high absolute monocyte count, extra-nodal lymphoma, and B symptoms. Nine patients showed low signal in digital PCR but were deemed positive for the MYD88 L265P mutation by the nested allele-specific PCR. The remaining 103 patients were negative according to the results of both the PCR analyses. With a median follow-up period of 64 months, the carriers of MYD88 L265P mutation exhibited inferior CNS relapse-free survival at 5 years with a significant effect of the mutation demonstrated by the multivariate analysis. This suggests that the MYD88 L265P mutation plays a critical role in the progression of DLBCL to CNS.
DOI	10.1016/j.leukres.2020.106426
文献番号	32781214