テルイ ヤスヒト
TERUI Yasuhito
照井 康仁 所属 埼玉医科大学 医学部 血液内科 職種 教授 |
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論文種別 | 学術雑誌(原著) |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | MYD88 L265P mutation detected by digital PCR as a prognostic factor in patients with diffuse large B-cell lymphoma in rituximab era |
掲載誌名 | 正式名:Leuk Res ISSNコード:18735835 |
掲載区分 | 国外 |
巻・号・頁 | 97,106426頁 |
著者・共著者 | Nishimura, N., Takeuchi, K., Asaka, R., Tuyama, N., Inoue, N., Kusano, Y., Mishima, Y., Yokoyama, M., Terui, Y. |
発行年月 | 2020 |
概要 | To test if the presence of the MYD88 L265P mutation is a prognostic factor for secondary CNS relapse, we carried out the digital PCR analysis of 134 samples from patients with DLBCL at diagnosis. The MYD88 L265P mutations were detected in 22 (16.4%) patients, particularly in those with a non-GC subtype, CD5-positive, high absolute monocyte count, extra-nodal lymphoma, and B symptoms. Nine patients showed low signal in digital PCR but were deemed positive for the MYD88 L265P mutation by the nested allele-specific PCR. The remaining 103 patients were negative according to the results of both the PCR analyses. With a median follow-up period of 64 months, the carriers of MYD88 L265P mutation exhibited inferior CNS relapse-free survival at 5 years with a significant effect of the mutation demonstrated by the multivariate analysis. This suggests that the MYD88 L265P mutation plays a critical role in the progression of DLBCL to CNS. |
DOI | 10.1016/j.leukres.2020.106426 |
文献番号 | 32781214 |