テルイ ヤスヒト
TERUI Yasuhito
照井 康仁 所属 埼玉医科大学 医学部 血液内科 職種 教授 |
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論文種別 | 学術雑誌(原著) |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | The clonal evolution during long-term clinical course of multiple myeloma |
掲載誌名 | 正式名:Int J Hematol ISSNコード:18653774 |
掲載区分 | 国外 |
巻・号・頁 | 113,279-284頁 |
著者・共著者 | Mishima, Y., Shirouchi, Y., Nishimura, N., Yokoyama, M., Okabe, T., Inoue, N., Uryu, H., Fukuta, T., Hatake, K., Terui, Y. |
発行年月 | 2021 |
概要 | In this study, we traced the transition of somatic mutations during the clinical course of myeloma patients over a long-term follow-up period (8.5 year average). Seven myeloma cases treated with immuno-chemotherapy at our institution were analyzed with clinical courses and the results of FISH and G-band analyses. Furthermore, the target sequences in regard to 121 genes, related to driver mutations or acceleration of disease in myeloma, were performed using bone marrow myeloma samples by next-generation sequencing, Ion Proton™ System. We detected a relationship between an increase in the dominant mutated gene (e.g., TP53, DIS3, FAM46C, KDM6B, and EGR1) and poor prognosis. In particular, clonal escalation of the TP53 mutation could not be overcome by any treatment. The selection of a combination treatment conducted in conjunction with the monitoring of gene mutations is appropriate for long-term survival. |
DOI | 10.1007/s12185-020-02979-7 |
文献番号 | 32864713 |