テルイ　ヤスヒト   TERUI Yasuhito   照井　康仁    所属   埼玉医科大学  医学部 血液内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The clonal evolution during long-term clinical course of multiple myeloma
掲載誌名	正式名：Int J Hematol ISSNコード：18653774
掲載区分	国外
巻・号・頁	113,279-284頁
著者・共著者	Mishima, Y., Shirouchi, Y., Nishimura, N., Yokoyama, M., Okabe, T., Inoue, N., Uryu, H., Fukuta, T., Hatake, K., Terui, Y.
発行年月	2021
概要	In this study, we traced the transition of somatic mutations during the clinical course of myeloma patients over a long-term follow-up period (8.5 year average). Seven myeloma cases treated with immuno-chemotherapy at our institution were analyzed with clinical courses and the results of FISH and G-band analyses. Furthermore, the target sequences in regard to 121 genes, related to driver mutations or acceleration of disease in myeloma, were performed using bone marrow myeloma samples by next-generation sequencing, Ion Proton™ System. We detected a relationship between an increase in the dominant mutated gene (e.g., TP53, DIS3, FAM46C, KDM6B, and EGR1) and poor prognosis. In particular, clonal escalation of the TP53 mutation could not be overcome by any treatment. The selection of a combination treatment conducted in conjunction with the monitoring of gene mutations is appropriate for long-term survival.
DOI	10.1007/s12185-020-02979-7
文献番号	32864713