テルイ ヤスヒト
TERUI Yasuhito
照井 康仁 所属 埼玉医科大学 医学部 血液内科 職種 教授 |
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論文種別 | 学術雑誌(原著) |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Impact of Omission/Reduction of Vincristine From R-CHOP in Treatment of DLBCL |
掲載誌名 | 正式名:Clin Lymphoma Myeloma Leuk ISSNコード:21522669 |
掲載区分 | 国外 |
巻・号・頁 | 21,162-169頁 |
著者・共著者 | Marshall, S., Nishimura, N., Inoue, N., Yamauchi, H., Tsuyama, N., Takeuchi, K., Mishima, Y., Yokoyama, M., Ogasawara, T., Mori, N., Ogawa, T., Sakura, H., Terui, Y. |
発行年月 | 2021 |
概要 | The R-CHOP regimen is the standard therapy for patients with DLBCL. However, vincristine is sometimes omitted or reduced owing to side effects.|We retrospectively reviewed newly diagnosed patients with DLBCL with R-CHOP-like chemotherapy in our institute from January 2005 to February 2018 to investigate whether the omission/reduction of vincristine reduced the efficacy of the treatment. We compared the OS with and without the omission/reduction of vincristine from the R-CHOP regimen.|A total of 576 cases were reviewed, and vincristine was omitted/reduced in 50 (9%) patients. The 4-year OS with and without vincristine omission/reduction for relative dose intensity < 80%, 50%, and 25% was 70% versus 82% (P = .035), 70% versus 82% (P = .085), and 53% versus 82% (P = .0007). |
DOI | 10.1016/j.clml.2020.12.017 |
文献番号 | 33483276 |