テルイ　ヤスヒト   TERUI Yasuhito   照井　康仁    所属   埼玉医科大学  医学部 血液内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Impact of Omission/Reduction of Vincristine From R-CHOP in Treatment of DLBCL
掲載誌名	正式名：Clin Lymphoma Myeloma Leuk ISSNコード：21522669
掲載区分	国外
巻・号・頁	21,162-169頁
著者・共著者	Marshall, S., Nishimura, N., Inoue, N., Yamauchi, H., Tsuyama, N., Takeuchi, K., Mishima, Y., Yokoyama, M., Ogasawara, T., Mori, N., Ogawa, T., Sakura, H., Terui, Y.
発行年月	2021
概要	The R-CHOP regimen is the standard therapy for patients with DLBCL. However, vincristine is sometimes omitted or reduced owing to side effects.|We retrospectively reviewed newly diagnosed patients with DLBCL with R-CHOP-like chemotherapy in our institute from January 2005 to February 2018 to investigate whether the omission/reduction of vincristine reduced the efficacy of the treatment. We compared the OS with and without the omission/reduction of vincristine from the R-CHOP regimen.|A total of 576 cases were reviewed, and vincristine was omitted/reduced in 50 (9%) patients. The 4-year OS with and without vincristine omission/reduction for relative dose intensity < 80%, 50%, and 25% was 70% versus 82% (P = .035), 70% versus 82% (P = .085), and 53% versus 82% (P = .0007).
DOI	10.1016/j.clml.2020.12.017
文献番号	33483276