テルイ ヤスヒト
TERUI Yasuhito
照井 康仁 所属 埼玉医科大学 医学部 血液内科 職種 教授 |
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論文種別 | 学術雑誌(原著) |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Phase I, multicenter, dose-escalation study of avadomide in adult Japanese patients with advanced malignancies |
掲載誌名 | 正式名:Cancer Sci ISSNコード:13497006 |
掲載区分 | 国外 |
巻・号・頁 | 112,331-338頁 |
著者・共著者 | Hatake, K., Chou, T., Doi, T., Terui, Y., Kato, H., Hirose, T., Seo, S., Pourdehnad, M., Ogaki, Y., Fujimoto, H., Hagner, P. R., Yamamoto, K. |
発行年月 | 2021 |
概要 | This phase I multicenter study evaluated avadomide in Japanese patients with advanced solid tumors or NHL. Fourteen patients with NHL and one with a solid tumor (esophageal carcinoma), were enrolled in four dose-escalation cohorts using a 3 + 3 design. Primary endpoints included safety, DLT, maximum-tolerated dose and/or recommended phase II dose (RP2D), and pharmacokinetics. Secondary endpoints included ORR and duration of response. One patient with NHL experienced DLT, which included face edema, pharyngeal edema, and tumor flare that led to a dose reduction. Eleven patients had grade ≥3 treatment-emergent adverse events, most frequently decreased neutrophil count (33%) and decreased lymphocyte count (20%). The ORR in patients with NHL (n = 13) was 54%, including four complete and three partial responses. |
DOI | 10.1111/cas.14704 |
文献番号 | 33075165 |