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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | The spectrum of clinicopathological features in pure autonomic neuropathy |
| 掲載誌名 | 正式名：Journal of Neurology ISSNコード：03405354 |
| 巻・号・頁 | 259(10),2067-2075頁 |
| 著者・共著者 | Haruki Koike,Rina Hashimoto,Minoru Tomita,Yuichi Kawagashira,Masahiro Iijima,Shigeru Koyano,Takayuki Momoo,Hiroyuki Yuasa,Shigehisa Mitake,Mana Higashihara,Kenichi Kaida,Daisuke Yamamoto,Shin Hisahara,Shun Shimohama,Yoshiharu Nakae,Ken Johkura,Steven Vernino,Gen Sobue |
| 発行年月 | 2012/10 |
| 概要 | We assessed the clinicopathological features of nine patients with pure autonomic neuropathy, that is, neuropathy without sensory or motor deficits. The duration from symptom onset to diagnosis ranged from 1 month to 13 years. Of eight patients in whom serum antiganglionic acetylcholine receptor antibody was determined, four were positive. All patients who tested positive for this antibody manifested widespread autonomic dysfunction, with the exception of one patient who only experienced orthostatic hypotension. However, patients who were negative for the antiganglionic acetylcholine receptor antibody presented with partial autonomic failure. One of these patients had diffuse parasympathetic failure and generalized hypohidrosis but no orthostatic hypotension, which is clinically compatible with postganglionic cholinergic dysautonomia. Electron microscopic examination revealed a variable degree of reduction in unmyelinated fibers. Compared with normal controls, the patients had a significantly increased density of collagen pockets (p<0.05). Additionally, the percentage of Schwann cell subunits with axons (out of the total number of Schwann cell subunits associated with unmyelinat |
| DOI | 10.1007/s00415-012-6458-x |
| PMID | 22361978 |