カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	日本語
査読の有無	査読あり
表題	[Immune-mediated neuropathy and anti-glycolipid antibodies].
掲載誌名	正式名：Brain and nerve = Shinkei kenkyu no shinpo ISSNコード：18816096
巻・号・頁	65(4),413-23頁
著者・共著者	Kenichi Kaida,Susumu Kusunoki
発行年月	2013/04
概要	Antibodies to glycolipids likely play a pathogenic role in the development of immune-mediated neuropathy. Guillain-Barre syndrome (GBS), an acute immune-mediated polyradiculoneuropathy, often has IgG antibodies to gangliosides, sialic acid-containing glycolipids. The heterogeneity of ganglioside expression in the peripheral nervous system (PNS) may underlie the differential clinical manifestation of GBS variants. Recent studies show that anti-ganglioside antibody-mediated complement activation plays a key role in the development of GBS and related disorders. Futher, complement-independent nerve dysfunction has been suggested by in vitro studies that anti-ganglioside antibodies directly inhibit voltage-gated Ca2+ channel currents and change the integrity of lipid rafts. These pathogenic actions of anti-ganglioside antibodies may be governed by the avidity of the antibodies, which is influenced by the specific localization of target gangliosides in the PNS, the glycolipid environment around the target antigens, the large amount of targeted gangliosides in specific regions, the steric microstructure of sialic acids in the gangliosides, or conformation of the glycoepitopes that are dep
PMID	23568989