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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Successful treatment of infliximab-associated immune-mediated sensory polyradiculopathy with intravenous immunoglobulin |
| 掲載誌名 | 正式名：Journal of Clinical Neuroscience ISSNコード：09675868 |
| 巻・号・頁 | 20(11),1618-1619頁 |
| 著者・共著者 | Hiroya Naruse,Yu Nagashima,Risa Maekawa,Takafumi Etoh,Ayumi Hida,Jun Shimizu,Ken-Ichi Kaida,Yasushi Shiio |
| 発行年月 | 2013/11 |
| 概要 | Infliximab, a tumor necrosis factor-alpha antagonist, is used to treat many inflammatory diseases. Various forms of demyelinating neuropathies have been reported as neurological complications associated with infliximab use. There have been few reports of pure sensory neuropathy associated with infliximab. We report the clinical, electrophysiological, and pathological findings of a patient with subacute sensory polyradiculopathy 1 month after infliximab therapy for psoriasis vulgaris. Immune-mediated pathogenesis was suggested by positive anti-ganglioside antibodies and rapid response to intravenous immunoglobulin. This is the first reported case of sensory polyradiculopathy with positive anti-ganglioside antibodies following infliximab therapy. Our findings suggest the clinical importance of immunological investigations and treatment in demyelinating neuropathies following infliximab therapy. © 2013 Elsevier Ltd. All rights reserved. |
| DOI | 10.1016/j.jocn.2012.12.016 |
| PMID | 23906523 |