カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Overlapping demyelinating syndromes and anti-N-methyl-D-aspartate receptor encephalitis
掲載誌名	正式名：Annals of Neurology ISSNコード：15318249
出版社	John Wiley and Sons Inc.
巻・号・頁	75(3),411-428頁
著者・共著者	Maarten J. Titulaer,Romana Höftberger,Takahiro Iizuka,Frank Leypoldt,Lindsey McCracken,Tania Cellucci,Leslie A. Benson,Huidy Shu,Takashi Irioka,Makito Hirano,Gagandeep Singh,Alvaro Cobo Calvo,Kenichi Kaida,Pamela S. Morales,Paul W. Wirtz,Tomotaka Yamamoto,Markus Reindl,Myrna R. Rosenfeld,Francesc Graus,Albert Saiz,Josep Dalmau
発行年月	2014
概要	Objective To report the clinical, radiological, and immunological association of demyelinating disorders with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods Clinical and radiological analysis was done of a cohort of 691 patients with anti-NMDAR encephalitis. Determination of antibodies to NMDAR, aquaporin-4 (AQP4), and myelin oligodendrocyte glycoprotein (MOG) was performed using brain immunohistochemistry and cell-based assays. Results Twenty-three of 691 patients with anti-NMDAR encephalitis had prominent magnetic resonance imaging (MRI) and/or clinical features of demyelination. Group 1 included 12 patients in whom anti-NMDAR encephalitis was preceded or followed by independent episodes of neuromyelitis optica (NMO) spectrum disorder (5 cases, 4 anti-AQP4 positive) or brainstem or multifocal demyelinating syndromes (7 cases, all anti-MOG positive). Group 2 included 11 patients in whom anti-NMDAR encephalitis occurred simultaneously with MRI and symptoms compatible with demyelination (5 AQ4 positive, 2 MOG positive). Group 3 (136 controls) included 50 randomly selected patients with typical anti-NMDAR encephalitis, 56 with NMO, and 30 with multiple sclerosis NM
DOI	10.1002/ana.24117
PMID	24700511