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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 日本語 |
| 査読の有無 | 査読あり |
| 表題 | A 53-year-old man with herpes encephalitis showing acceleration of improvement in higher brain function after general anesthesia with sevoflurane: A case report |
| 掲載誌名 | 正式名：Clinical Neurology ISSNコード：0009918X |
| 出版社 | Societas Neurologica Japonica |
| 巻・号・頁 | 54(9),743-746頁 |
| 著者・共著者 | Naohiko Togashi,Kenichi Kaida,Yu Hongo,Go Ogawa,Yukinobu Ishikawa,Katsuhiko Takeda,Keiko Kamakura |
| 発行年月 | 2014 |
| 概要 | We experienced a right-handed 53-year-old man who presented with disturbance of consciousness and fever. Herpes simplex encephalitis (HSE) was diagnosed based on the detection of herpes simplex virus DNA in the cerebrospinal fluid. The administration of acyclovir for 42 days improved his consciousnesslevel. Drowsiness, fever and seizures reappeared 20 days after stopping acyclovir treatment (day 67) and he responded well to vidarabine and methylprednisolone pulse therapy. An assessment of aphasia on day 98 revealed transcortical sensory aphasia. Brain MRI showed lesion in the left temporal lobe, bilateral insular cortexes and bilateral frontal lobe. His higher brain dysfunction continued. On day 156, he underwent hip replacement arthroplasty under general anesthesia sevoflurane. His higher brain dysfunction rapidly improved thereafter. We concluded that the accelerated improvement in our patient's higher brain function was related to the protective effect of sevoflurane. Some reports also show the protective effects of sevoflurane in experimental allergic encephalomyelitis by inhibition of T cell activation. These protective and anti-inflammatory effects may explain the accelerate |
| DOI | 10.5692/clinicalneurol.54.743 |
| PMID | 25283830 |