カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Paranodal dissectionin chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies
掲載誌名	正式名：Journal of Neurology, Neurosurgery and Psychiatry ISSNコード：1468330X
出版社	BMJ Publishing Group
巻・号・頁	88(6),465-473頁
著者・共著者	Haruki Koike,Masato Kadoya,Ken-Ichi Kaida,Shohei Ikeda,Yuichi Kawagashira,Masahiro Iijima,Daisuke Kato,Hidenori Ogata,Ryo Yamasaki,Noriyuki Matsukawa,Jun-Ichi Kira,Masahisa Katsuno,Gen Sobue
発行年月	2017/06
概要	Objective To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularly focusing on the fine structures of the paranodes. Methods We assessed sural nerve biopsy specimens obtained from 9 patients with CIDP with anti-neurofascin-155 antibodies and 1 patient with anti-contactin-1 antibodies. 13 patients with CIDP without these antibodies were also examined to compare pathological findings. Results Characteristic light and electron microscopy findings in transverse sections from patients with anti-neurofascin-155 and anti-contactin-1 antibodies indicated a slight reduction in myelinated fibre density, with scattered myelin ovoids, and the absence of macrophage-mediated demyelination or onion bulbs. Teased-fibre preparations revealed that segmental demyelination tended to be found in patients with relatively higher frequencies of axonal degeneration and was tandemly found at consecutive nodes of Ranvier in a single fibre. Assessment of longitudinal sections by electron microscopy revealed that detachment of terminal myelin loops from the axolemma was frequently foun
DOI	10.1136/jnnp-2016-314895
PMID	28073817