カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Clinicopathologic features of myositis patients with CD8-MHC-1 complex pathology
掲載誌名	正式名：Neurology ISSNコード：1526632X
出版社	Lippincott Williams and Wilkins
巻・号・頁	89(10),1060-1068頁
著者・共著者	Chiseko Ikenaga,Akatsuki Kubota,Masato Kadoya,Kenichiro Taira,Naohiro Uchio,Ayumi Hida,Meiko Hashimoto Maeda,Yu Nagashima,Hiroyuki Ishiura,Kenichi Kaida,Jun Goto,Shoji Tsuji,Jun Shimizu
発行年月	2017/09
概要	To determine the clinical features of myositis patients with the histopathologic finding of CD8-positive T cells invading non-necrotic muscle fibers expressing major histocompatibility complex class 1 (CD8-MHC-1 complex), which is shared by polymyositis (PM) and inclusion body myositis (IBM), in relation to the p62 immunostaining pattern of muscle fibers. Methods: All 93 myositis patients with CD8-MHC-1 complex who were referred to our hospital from 1993 to 2015 were classified on the basis of the European Neuromuscular Center (ENMC) diagnostic criteria for IBM (Rose, 2013) or PM (Hoogendijk, 2004) and analyzed. Results: The 93 patients included were 17 patients with PM, 70 patients with IBM, and 6 patients who neither met the criteria for PM nor IBM in terms of muscle weakness distribution (unclassifiable group). For these PM, IBM, and unclassifiable patients, their mean ages at diagnosis were 63, 70, and 64 years autoimmune disease was present in 7 (41%), 13 (19%), and 4 (67%) hepatitis C virus infection was detected in 0%, 13 (20%), and 2 (33%) and p62 was immunopositive in 0%, 66 (94%), and 2 (33%), respectively. Of the treated patients, 11 of 16 PM patients and 4 of 6 p62-i
DOI	10.1212/WNL.0000000000004333
PMID	28794251