カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study.
掲載誌名	正式名：Journal of the peripheral nervous system : JPNS
巻・号・頁	22(4),433-439頁
著者・共著者	Yuko Yamagishi,Hidekazu Suzuki,Masahiro Sonoo,Satoshi Kuwabara,Takanori Yokota,Kyoichi Nomura,Atsuro Chiba,Ryuji Kaji,Takashi Kanda,Kenichi Kaida,Shu-Ichi Ikeda,Tatsuro Mutoh,Ryo Yamasaki,Hiroshi Takashima,Makoto Matsui,Kazutoshi Nishiyama,Gen Sobue,Susumu Kusunoki
発行年月	2017/12
概要	Guillain-Barré syndrome (GBS) is an acute monophasic neuropathy. Prognostic tools include the modified Erasmus GBS outcome score (mEGOS), Erasmus GBS respiratory insufficiency score (EGRIS), and the increase in serum IgG levels (ΔIgG) 2 weeks after intravenous immunoglobulin (IVIg) treatment. Given that proportions of GBS subtypes differ between Western countries and Japan, the usefulness of these tools in Japan or other countries remains unknown. We enrolled 177 Japanese patients with GBS from 15 university hospitals and retrospectively obtained mEGOS and EGRIS for all and ΔIgG status for 79 of them. High mEGOS scores on admission or on day 7 were significantly associated with poorer outcomes (unable to walk independently at 6 months). High EGRIS scores (≥5 points) were associated with an increased risk for mechanical ventilation. Patients with ΔIgG<1,108 mg/dl had significantly poorer outcomes. We suggest that mEGOS, EGRIS, and ΔIgG in GBS are clinically relevant in Japan.
DOI	10.1111/jns.12234
PMID	28833828