カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	日本語
査読の有無	査読あり
表題	A 15-year-old girl with congenital cytomegalovirus infection presenting with sensorineural hearing impairment and cerebral while matter lesions but no intellectual disability
掲載誌名	正式名：Clinical Neurology ISSNコード：0009918X
出版社	Societas Neurologica Japonica
巻・号・頁	58(5),320-323頁
著者・共著者	Keiichi Nakagawa,Masato Kadoya,Hiroshi Matsumoto,Hiroyuki Moriuchi,Katsunori Ikewaki,Kenichi Kaida
発行年月	2018
概要	A 15-year-old girl presented with non-progressive sensorineural hearing impairment in her right ear since her early childhood. She had normal intellectual development. When she was 15 years old, small deep white matter lesions around the lateral ventricles were incidentally detected in brain MRI studies through further investigation of auditory organs. Laboratory data including cerebrospinal fluid analysis and antibodies to aquaporin-4 or myelin-oligodendrocyte glycoprotein were normal. She was diagnosed as a congenital cytomegalovirus (CMV) infection based on the detection of CMV DNA from preserved umbilical cord tissue by real-time polymerase chain reaction. It should be kept in mind that a case of congenital CMV infection with normal intelligence may be underdiagnosed and that sensorineural hearing impairment from early childhood and deep white matter abnormalities can be key features giving rise to suspicion on congenital CMV infection.
DOI	10.5692/clinicalneurol.cn-001164
PMID	29710020