カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Clinical features of acute flaccid myelitis temporally associated with an enterovirus D68 outbreak: Results of a nationwide survey of acute flaccid paralysis in Japan, August-December 2015
掲載誌名	正式名：Clinical Infectious Diseases ISSNコード：15376591
出版社	Oxford University Press
巻・号・頁	66(5),653-664頁
著者・共著者	Pin Fee Chong,Ryutaro Kira,Harushi Mori,Akihisa Okumura,Hiroyuki Torisu,Sawa Yasumoto,Hiroyuki Shimizu,Tsuguto Fujimoto,Nozomu Hanaoka,Susumu Kusunoki,Toshiyuki Takahashi,Kazunori Oishi,Keiko Tanaka-Taya,Etsushi Toyofuku,Tetsuhiro Fukuyama,Tatsuharu Sato,Yuya Takahashi,Akane Kanazawa,Masato Hiyane,Takao Fukushima,Taira Toki,Ryoko Hayashi,Sonoko Kubota,Wakako Ishii,Manami Akasaka,Haruna Miyazawa,Mitsuo Motobayashi,Mari Asaoka,Takashi Shiihara,Yoshitaka Miyoshi,Tomohiko Tsuru,Kenta Ikeda,Masaru Matsukura,Ryoko Nakamura,Kengo Moriyama,Yuji Sugawara,Yuichi Takami,Takako Fujita,Tamami Yano,Mariko Kasai,Takashi Uchida,Masashi Fujita,Mitsugu Uematsu,Atsuko Hata,Hideto Ogata,Tomoyuki Miyamoto,Kataharu Sumi,Yu Ishida,Eri Takeshita,Tomoya Kawazoe,Takayoshi Kawabata,Chiharu Miyatake,Akiko Yakuwa,Yu Kakimoto,Hiroshi Terashima,Masaya Kubota,Yuichi Abe,Michiaki Nagura,Hideo Yamanouchi,Satomi Mori,Yukihiko Konishi,Mariko Ikegami,Yuko Tomonaga,Yumiko Takashima,Kazushi Ichikawa,Nobuko Moriyama,Chizu Oba,Mitsuru Kashiwagi,Sosuke Yoshikawa,Kenichi Tanaka,Genrei Ohta,Ayako Hattori,Daisuke Ieda,Sahoko Ono,Tomoshige Tanimura,Kyoko Ban,Nobuyoshi Sugiyama,Nozomi Kouzan,Yuki Yamada,Mika Inoue,Kenichi Sakajiri,Ken Ohyama,Miho Yamamuro,Hidetoshi Ishigaki,Azusa Seino,Shuichi Igarashi,Takahito Nakamoto,Kanae Sugimoto,Mitsuhiro Ochi,Eri Hamanaka,Kazuki Ohi,Hidefumi Kawasaki,Masahiko Nishitani,Hiroshi Uno,Masaru Inoue,Mai Okuyama,Ayako Yamamoto,Ryota Sato,Norihiko Azuma,Sakiko Mabuchi,Yoko Shida,Yu Hashimoto,Motoi Yoshimura,Yuki Matsuhisa,Kotaro Nakano,Yukio Yamashita,Eriko Kikuchi,Asuka Yamamoto,Naru Igarashi,Noboru Yoshida,Shingo Nishiki,Daisuke Yasutomi,Nobuyoshi Kusano,Ryohei Wakahara,Masayuki Furuyama,Hitoshi Mikami,Hiroaki Taniguchi,Yasuhiro Yoshii,Atsushi Narabayashi,Tomofumi Nakamura,Yasuo Kaburagi,Akiko Nagasao,Motoi Kuwahara,Kenichi Kaida
発行年月	2018/03
概要	Background. Acute flaccid myelitis (AFM) is an acute flaccid paralysis syndrome with spinal motor neuron involvement of unknown etiology. We investigated the characteristics and prognostic factors of AFM clusters coincident with an enterovirus D68 (EV-D68) outbreak in Japan during autumn 2015. Methods. An AFM case series study was conducted following a nationwide survey from August to December 2015. Radiographic and neurophysiologic data were subjected to centralized review, and virology studies were conducted for available specimens. Results. Fifty-nine AFM cases (58 definite, 1 probable) were identified, including 55 children and 4 adults (median age, 4.4 years). Te AFM epidemic curve showed strong temporal correlation with EV-D68 detection from pathogen surveillance, but not with other pathogens. EV-D68 was detected in 9 patients: 5 in nasopharyngeal, 2 in stool, 1 in cerebrospinal fluid (adult case), and 1 in tracheal aspiration, nasopharyngeal, and serum samples (a pediatric case with preceding steroid usage). Cases exhibited heterogeneous paralysis patterns from 1-to 4-limb involvement, but all definite cases had longitudinal spinal gray matter lesions on magnetic resonance i
DOI	10.1093/cid/cix860