イワセ　サトル   Iwase Satoru   岩瀬　哲    所属   埼玉医科大学  医学部 緩和医療科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Efficacy of oral administration of cystine and theanine in colorectal cancer patients undergoing capecitabine-based adjuvant chemotherapy after surgery: a multi-institutional, randomized, double-blinded, placebo-controlled, phase II trial (JORTC-CAM03).
掲載誌名	正式名：Supportive Care in Cancer 略　 称：Support Care Cancer. ISSNコード：14337339
掲載区分	国外
出版社	Springer
巻・号・頁	28(8),3649-3657頁
著者・共著者	Hamaguchi R, Tsuchiya T, Miyata G, Sato T, Takahashi K, Miura K, Oshio H, Ohori H, Ariyoshi K, Oyamada S, Iwase S.
発行年月	2020/08/01
概要	Capecitabine-based adjuvant chemotherapy for colorectal cancer patients often causes adverse events (AEs), such as diarrhea, stomatitis, anorexia, and hand-foot syndrome (HFS). Cystine and theanine were reported to attenuate some chemotherapy-associated AEs, and hence are also expected to attenuate capecitabine-induced AEs. Therefore, we aimed to investigate the safety and efficacy of cystine/theanine treatment in colorectal cancer patients undergoing capecitabine-based adjuvant chemotherapy after surgery. This trial demonstrated that cystine/theanine treatment of colorectal cancer patients undergoing capecitabine-based adjuvant chemotherapy after surgery is safe and has the tendency to reduce the incidence rate of diarrhea or HFS.