マキノ　ヨシノリ   MAKINO Yoshinori   牧野　好倫    所属   埼玉医科大学  医学部 国際医療センター　がんゲノム医療科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant.
掲載誌名	正式名：European Journal of Clinical Pharmacology 略　 称：Eur J Clin Pharmacol
掲載区分	国外
巻・号・頁	78(4),613-621頁
総ページ数	9
著者・共著者	Hideyuki Hibino, Naomi Sakiyama, Yoshinori Makino, Reiko Makihara-Ando, Hidehito Horinouchi, Yutaka Fujiwara, Shintaro Kanda, Yasushi Goto, Tatsuya Yoshida, Yusuke Okuma, Yuki Shinno, Shuji Murakami, Hironobu Hashimoto, Takeshi Akiyoshi, Ayuko Imaoka, Yuichiro Ohe, Masakazu Yamaguchi, Hisakazu Ohtani.
発行年月	2022/04/01
概要	Aprepitant is used with dexamethasone and 5-HT3 receptor antagonists as an antiemetic treatment for chemotherapy, including cisplatin. Aprepitant is a substrate of cytochrome P450 (CYP) 3A4 and is known to cause its inhibition and induction. In addition, dexamethasone is a CYP3A4 substrate that induces CYP3A4 and CYP3A5 expression. In this study, we aimed to quantitatively evaluate the profile of CYP3A activity using its endogenous markers in non-small cell lung cancer patients receiving a standard cisplatin regimen with antiemetics, including aprepitant. CYP3A activity was significantly induced from day 4 to day 8 in patients receiving cisplatin and three antiemetic drugs.
researchmap用URL	https://link.springer.com/article/10.1007/s00228-022-03275-5