ヤマダ　タケト   YAMADA Taketo   山田　健人    所属   埼玉医科大学  医学部 病理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Blockade of CD26 Signaling Inhibits Human Osteoclast Development
掲載誌名	正式名：J Bone Mineral Research
掲載区分	国外
巻・号・頁	29(11),2439-2455頁
著者・共著者	Nishida H, Suzuki H, Madokoro H, Hayashi M, Morimoto C, Sakamoto M, Yamada T
発行年月	2014/11
概要	We herein show that CD26 is preferentially expressed on normal human OCs and is intensely expressed on activated human OCs in osteolytic bone alterations. The humanized anti-CD26 monoclonal antibody, huCD26mAb, impaired the formation and function of tartrate-resistant acid phosphatase (TRAP)/CD26 positive multi-nucleated OCs with maturation in the manner of dose-dependency. It was revealed that huCD26mAb inhibits early OC differentiation via the inactivation of MKK3/6, p38 MAPK and subsequent dephospho rylation of microphthalmia-associated transcription factor.