ヤマダ タケト   YAMADA Taketo
  山田 健人
   所属   埼玉医科大学  医学部 病理学
   職種   教授
論文種別 学術雑誌(原著)
言語種別 英語
査読の有無 査読あり
表題 Blockade of CD26 Signaling Inhibits Human Osteoclast Development
掲載誌名 正式名:J Bone Mineral Research
巻・号・頁 29(11),2439-2455頁
著者・共著者 Nishida H, Suzuki H, Madokoro H, Hayashi M, Morimoto C, Sakamoto M, Yamada T
発行年月 2014/11
概要 We herein show that CD26 is preferentially expressed on normal human OCs and is intensely expressed on activated human OCs in osteolytic bone alterations. The humanized anti-CD26 monoclonal antibody, huCD26mAb, impaired the formation and function of tartrate-resistant acid phosphatase (TRAP)/CD26 positive multi-nucleated OCs with maturation in the manner of dose-dependency. It was revealed that huCD26mAb inhibits early OC differentiation via the inactivation of MKK3/6, p38 MAPK and subsequent dephospho rylation of microphthalmia-associated transcription factor.