ヤマダ　タケト   YAMADA Taketo   山田　健人    所属   埼玉医科大学  医学部 病理学    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Modulation of immunological responses and amelioration of collagen-induced arthritis by the novel roxithromycin derivative 5-I
掲載誌名	正式名：Modern Rheumatology
巻・号・頁	25(4),562-570頁
著者・共著者	Otsuki N, Iwata S, Yamada T, Hosono O, Dang NH, Hatano R, Ohnuma K, Morimoto C
発行年月	2015/01
概要	5-I specifically inhibited production of Th1, Th17, and proinflammatory cytokines such as IL-2, IFN-γ, TNF-α, IL-6, and IL-17A. 5-I reduced the expression of RORC on CD4(+) T cells, which codes for RORγt, the master regulator of Th17, and it also inhibited migration of activated T cells. Importantly, administration of 5-I to mice with collagen-induced arthritis reduced the severity of arthritis, and this effect was also observed when treatment was delayed till after the onset of disease.