オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain.
掲載誌名	正式名：Synapse (New York, N.Y.) ISSNコード：08874476
出版社	WILEY-LISS
巻・号・頁	52(4),283-91頁
著者・共著者	Jun Maeda,Tetsuya Suhara,Ming-Rong Zhang,Takashi Okauchi,Fumihiko Yasuno,Yoko Ikoma,Motoki Inaji,Yuji Nagai,Akihiro Takano,Shigeru Obayashi,Kazutoshi Suzuki
発行年月	2004/06
概要	Peripheral benzodiazepine receptor (PBR) is expressed in most organs and its expression is reported to be increased in activated microglia in the brain. [(11)C]PK11195 has been widely used for the in vivo imaging of PBRs, but its signal in the brain was not high enough for stable quantitative analysis. We synthesized a novel positron emission tomography (PET) ligand, [(11)C]DAA1106, for PBR and investigated its in vivo properties in rat and monkey brain. High uptake of [(11)C]DAA1106 was observed in the olfactory bulb and choroid plexus area, followed by the pons/medulla and cerebellum by in vivo autoradiography of rat brain, correlating with the binding in vitro. [(11)C]DAA1106 binding was increased in the dorsal hippocampus with neural destruction, suggesting glial reaction. [(11)C]DAA1106 binding was both inhibited and displaced by 1.0 mg/kg of DAA1106 and 5 mg/kg of PK11195 by 80% and 70%, respectively. Specific binding was estimated as 80% of total binding. [(11)C]DAA1106 binding was four times higher compared to the binding of [(11)C]PK11195 in the monkey occipital cortex. These results indicated that [(11)C]DAA1106 might be a good ligand for invivo imaging of PBR.
DOI	10.1002/syn.20027
PMID	15103694