オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Relation between cortical dopamine D(2) receptor occupancy and suppression of conditioned avoidance response in non-human primate.
掲載誌名	正式名：Psychiatry and clinical neurosciences ISSNコード：13231316
出版社	BLACKWELL PUBLISHING ASIA
巻・号・頁	58(3),330-2頁
著者・共著者	Akihiro Takano,Tetsuya Suhara,Jun Maeda,Kiyoshi Ando,Takashi Okauchi,Shigeru Obayashi,Takashi Nakayama,Shitij Kapur
発行年月	2004/06
概要	Suppression of the conditioned avoidance response (CAR), a useful test for screening for antipsychotic effects, has been discussed in relation to the blockade of dopaminergic transmission. The purpose of the present paper was to investigate the relationship between cortical dopamine D(2) receptor occupancy and the suppression of CAR by haloperidol in non-human primate. The avoidance rate was measured for four different doses of haloperidol treatment in a rhesus monkey, and the cortical D(2) receptor occupancy was measured in a parallel session using positron emission tomography with [(11)C]FLB 457. The successful avoidance response rate was decreased for doses of 10 and 30 microg/kg of haloperidol, and this decrement was associated with 65-77% of D(2) receptor occupancy. It is suggested that the threshold level of cortical dopamine D(2) receptor occupancy for the suppression of CAR is demonstrated in the present study.
DOI	10.1111/j.1440-1819.2004.01240.x
NAID	10014373772
PMID	15149302