オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats.
掲載誌名	正式名：Brain research ISSNコード：00068993
出版社	ELSEVIER SCIENCE BV
巻・号・頁	1064(1-2),136-45頁
著者・共著者	Motoki Inaji,Takashi Okauchi,Kiyoshi Ando,Jun Maeda,Yuji Nagai,Takahito Yoshizaki,Hideyuki Okano,Tadashi Nariai,Kikuo Ohno,Shigeru Obayashi,Makoto Higuchi,Tetsuya Suhara
発行年月	2005/12
概要	We evaluated correlation between neurochemical and functional alterations of the nigrostriatal dopaminergic system in rat brains lesioned with 6-hydroxydopamine (6-OHDA), that model hemi-Parkinson's disease (PD), by using three different quantitative in vivo and in vitro methods. Rats unilaterally lesioned with different doses of 6-OHDA underwent two types of in vivo experiments: (1) a rotational behavioral study with methamphetamine (MAP) or apomorphine (APO); and (2) a positron emission tomography (PET) study with [11C]PE2I (radioligand for dopamine transporters) or [11C]raclopride (radioligand for dopamine D2 receptors). An in vitro autoradiographic study with the same radioligands was also conducted. The number of rotations after the MAP or APO injection increased with increased doses of 6-OHDA. The in vitro and in vivo binding of [11C]PE2I dose-dependently decreased in response to the 6-OHDA injections, while that of [11C]raclopride dose-dependently increased. There was a significant negative hyperbolic correlation between the number of rotations after MAP injection and the binding of [11C]PE2I. In contrast, there was a significant positive linear correlation between the numbe
DOI	10.1016/j.brainres.2005.09.055
PMID	16298352