オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats.
掲載誌名	正式名：Cell transplantation ISSNコード：09636897
出版社	COGNIZANT COMMUNICATION CORP
巻・号・頁	14(9),655-63頁
著者・共著者	Motoki Inaji,Takahito Yoshizaki,Takashi Okauchi,Jun Maeda,Yuji Nagai,Tadashi Nariai,Kikuo Ohno,Kiyoshi Ando,Hideyuki Okano,Shigeru Obayashi,Tetsuya Suhara
発行年月	2005
概要	Positron emission tomography (PET) is a useful tool to assess and visualize neurotransmissions in vivo. In this study, we performed repeated PET scans with [11C]PE2I, a tracer of the dopamine transporter, to evaluate the alteration of the expression of dopamine (DA) transmission component after a fetal mesencephalic transplantation. The fetal mesencephalic cells were transplanted into the striatum of unilateral 6-OHDA-lesioned rats. PET scans with [11C]PE2I were performed to evaluate the DA transporter before and 2 and 4 weeks after the transplantation. Rotation behavior tests, in vitro autoradiography, measurements of DA contents in the striatum by high-performance liquid chromatography (HPLC), and tyrosine hydroxylase (TH) immunohistological examinations were performed at the same time points and examined for their relationship to changes in the dopamine transporter. The number of ipsilateral rotations induced by methamphetamine injections decreased. DA contents in the striatum measured with HPLC significantly increased. In the PET study, the binding potential of [11C]PE2I increased at 4 weeks. The results of the in vitro autoradiography study corresponded with those of the PET s
DOI	10.3727/000000005783982684
PMID	16405076