オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets.
掲載誌名	正式名：Psychopharmacology ISSNコード：00333158
出版社	4
巻・号・頁	195(4),509-16頁
著者・共著者	Kiyoshi Ando,Jun Maeda,Motoki Inaji,Takashi Okauchi,Shigeru Obayashi,Makoto Higuchi,Tetsuya Suhara,Yoshikuni Tanioka
発行年月	2008/01
概要	OBJECTIVE: Establishment of preclinical method evaluating behavioral protective actions of drugs for Parkinson's disease was attempted using l-deprenyl (DEP) as a reference drug in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-treated common marmosets. MATERIALS AND METHODS: Fifteen marmosets received MPTP at 2 mg/kg, subcutaneously (s.c.) per day for three consecutive days. To these marmosets, intragastric (i.g.) administration of DEP at 10 mg/kg was pretreated 2 h before each MPTP administration in DEP3 group and pretreated only in the first MPTP administration day in DEP1 group. As a control, distilled water (DW) was pretreated before each MPTP administration (n = 5 for each of three groups). RESULTS: In DW group, decreased daily activity counts and increased dysfunction scores were persistently observed for 3 weeks after MPTP. In DEP groups, the similar changes of both levels to those in DW group were temporally observed after MPTP for several days and then the values recovered to the pre-MPTP levels. The results of autoradiography performed after above behavioral observations indicated that markedly lower bindings of [(11)C]PE2I (ligand for dopamine transporters) were
DOI	10.1007/s00213-007-0929-2
PMID	17879087