オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別
査読の有無	査読あり
表題	Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo
掲載誌名	正式名：Synapse ISSNコード：08874476
巻・号・頁	41(2),172-175頁
著者・共著者	Takashi Okauchi,Tetsuya Suhara,Jun Maeda,Kouichi Kawabe,Shigeru Obayashi,Kazutoshi Suzuki
発行年月	2001
概要	The activity of DOPA decarboxylase measured in homogenates from rat striatum, or calculated from the rate of tracer decarboxylation measured ex vivo, is stimulated following acute treatment with antagonists of dopamine D2-like receptors. We used compartmental kinetics to test the hypothesis that utilization of the DOPA decarboxylase substrate [18F]fluorodopa is potentiated in living striatum following acute treatment with a typical neuroleptic. The kinetics of the tracer uptake were determined in eight anesthetized female pigs (40 kg) and in three animals receiving an infusion of haloperidol (75 μg kg-1 h-1) for 1 h prior to tracer administration and throughout the 2-h positron emission recording. The relative activity of DOPA decarboxylase in striatum was increased threefold by the treatment. This potentiation of DOPA decarboxylation after pharmacological blockade of dopamine D2-like receptors may be used to optimize the utilization of exogenous DOPA in the treatment of Parkinson's disease. © 2001 Wiley-Liss, Inc.
DOI	10.1002/syn.1071
PMID	11400183