オオバヤシ　シゲル   OBAYASHI Shigeru   大林　茂    所属   埼玉医科大学  医学部 総合医療センター　リハビリテーション科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	PET analysis of dopaminergic neurodegeneration in relation to immobility in the MPTP-treated common marmoset, a model for Parkinson's disease.
掲載誌名	正式名：PloS one ISSNコード：19326203
出版社	PUBLIC LIBRARY SCIENCE
巻・号・頁	7(10),e46371頁
著者・共著者	Kiyoshi Ando,Shigeru Obayashi,Yuji Nagai,Arata Oh-Nishi,Takafumi Minamimoto,Makoto Higuchi,Takashi Inoue,Toshio Itoh,Tetsuya Suhara
発行年月	2012
概要	BACKGROUND: Positron Emission Tomography (PET) measurement was applied to the brain of the common marmoset, a small primate species, treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The marmoset shows prominent Parkinson's disease (PD) signs due to dopaminergic neural degeneration. Recently, the transgenic marmoset (TG) carrying human PD genes is developing. For phenotypic evaluations of TG, non-invasive PET measurement is considered to be substantially significant. As a reference control for TG, the brain of the MPTP-marmoset as an established and valid model was scanned by PET. Behavioral analysis was also performed by recording locomotion of the MPTP-marmoset, as an objective measure of PD signs. METHODOLOGY/PRINCIPAL FINDINGS: MARMOSETS RECEIVED SEVERAL MPTP REGIMENS (SINGLE MPTP REGIMEN: 2 mg/kg, s.c., per day for 3 consecutive days) were used for PET measurement and behavioral observation. To measure immobility as a central PD sign, locomotion of marmosets in their individual living cages were recorded daily by infrared sensors. Daily locomotion counts decreased drastically after MPTP regimens and remained diminished for several months or more. PET scan of th
DOI	10.1371/journal.pone.0046371
PMID	23056291