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オオバヤシ シゲル
OBAYASHI Shigeru
大林 茂 所属 埼玉医科大学 医学部 総合医療センター リハビリテーション科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: a positron emission tomography study. |
| 掲載誌名 | 正式名：Neuroscience research ISSNコード：01680102 |
| 出版社 | ELSEVIER IRELAND LTD |
| 巻・号・頁 | 73(1),61-7頁 |
| 著者・共著者 | Yuji Nagai,Takafumi Minamimoto,Kiyoshi Ando,Shigeru Obayashi,Hiroshi Ito,Nobuhiko Ito,Tetsuya Suhara |
| 発行年月 | 2012/05 |
| 概要 | Parkinson's disease (PD) patients have remarkably reduced levels of dopaminergic biomarkers in the caudal putamen. However, the relationship between motor impairments and the localization of intrastriatal dopaminergic degeneration in monkey PD models remains unclear. To identify the striatal areas with dopaminergic dysfunction responsible for motor impairments, we measured changes in both general motor activity and in vivo dopaminergic biomarkers in three cynomolgus monkeys that repeatedly received 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), starting in the normal state and continuing until after tremor appearance. Binding of dopamine transporters (DAT) and D(2) receptors were measured by positron emission tomography (PET) using [(11)C]PE2I and [(11)C]raclopride, respectively. Region-of-interest-based regression analysis demonstrated the degree of general motor activity reduction to be explained by striatal DAT binding but not by D(2) receptor binding. Furthermore, voxel-based analysis revealed a significant correlation between reduced general motor activity and decreased DAT binding, specifically in the ventrolateral putamen, which corresponds to the area receiving upper |
| DOI | 10.1016/j.neures.2012.02.007 |
| PMID | 22374309 |