コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Neonatal Onset Diffuse Cutaneous Mastocytosis: A Case Report and Review of the Literature
掲載誌名	正式名：PEDIATRIC DERMATOLOGY ISSNコード：07368046
出版社	WILEY-BLACKWELL
巻・号・頁	28(5),542-546頁
著者・共著者	Hiroshi Koga,Takayuki Kokubo,Mutsumi Akaishi,Koichi Iida,Seigo Korematsu
発行年月	2011/09
概要	Diffuse cutaneous mastocytosis is a rare variant of mast cell disease with widespread erythroderma, which is normally clinically apparent in early infancy. We report the case of a neonate who presented with diffuse erythrodermic rash and bullous lesions. Biopsy specimens showed a dense dermal infiltrate of mast cells. Serum histamine and tryptase levels were elevated. No somatic mutation of the c-kit gene was found. Blistering ceased at 5 months of age, but atopic dermatitis appeared at 6 months and allergic workup revealed a high level of food-specific IgE. Herein, we describe the case and provide the first review of the literature on neonatal onset diffuse cutaneous mastocytosis to clarify the prognosis of this condition.
DOI	10.1111/j.1525-1470.2010.01212.x
PMID	20678092