コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Elevated umbilical cord serum TARC/CCL17 levels predict the development of atopic dermatitis in infancy
掲載誌名	正式名：CLINICAL AND EXPERIMENTAL ALLERGY ISSNコード：09547894
出版社	WILEY-BLACKWELL PUBLISHING, INC
巻・号・頁	41(2),186-191頁
著者・共著者	H. Miyahara,N. Okazaki,T. Nagakura,S. Korematsu,T. Izumi
発行年月	2011/02
概要	Background Thymus-and-activation-regulated chemokine (TARC; CCL17) is related to both allergy and pregnancy, but the relationships of maternal and umbilical cord blood CCL17 to atopic dermatitis (AD) development have not yet been examined. Objective Seventy paired full-term and normal vaginal delivery newborns and their mothers were enrolled in this study.Methods To elucidate the pathogenesis and fetomaternal inheritance of AD in infancy, CCL17, IFN-gamma-inducible protein 10 kDa (IP-10; CXCL10), soluble HLA-G (sHLA-G), IgE and eosinophil counts were examined using sera from 70 paired umbilical cord and maternal blood samples.Results Serum CCL17 (r(s) = 0.340, P<0.001) and sHLA-G (r(s) = 0.600, P<0.001) levels showed high correlations between umbilical cord and maternal blood. Umbilical cord serum levels of CCL17 from neonates destined to develop AD in infancy were higher than in those from neonates who showed no signs of AD during infancy (median 1586.9 vs. 819.6 pg/mL, P<0.001). Serum levels of CCL17 were higher in mothers with AD than inthose without AD (median 909.6 vs. 214.1 pg/mL, P<0.001). High umbilical cord serum levels of CCL17 were associated with infantil
DOI	10.1111/j.1365-2222.2010.03634.x
PMID	21054588