コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Human gamma delta T cells modulate the mite allergen-specific T-helper type 2-skewed immunity
掲載誌名	正式名：CLINICAL AND EXPERIMENTAL ALLERGY ISSNコード：09547894
出版社	BLACKWELL PUBLISHING
巻・号・頁	37(11),1681-1687頁
著者・共著者	S. Korematsu,Y. Tanaka,T. Nagakura,N. Minato,T. Izumi
発行年月	2007/11
概要	Backgournd gamma delta T cells have been described as one of immune regulators in patients with infection, malignancy, and allergy.Objective To elucidate the ability of gamma delta T cells as an allergen immunotherapy candidate, the effectiveness of human gamma delta T cells in allergen-specific T-helper type 2 (Th2)-type T cells was evaluated in vitro.Methods House dust mite-specific Th2-type T cell clones, Bacillus Calmette-Guerin (BCG)-specific Th1-type T cell clones, and gamma delta T cell lines were established from the peripheral blood mononuclear cells of two patients with allergic rhinitis. The effectiveness of gamma delta T cells and BCG-specific Th1-type T cell clones in the modulation of allergen-specific Th2 cells in terms of their cytokine productions was evaluated.Results In response to cognate antigens, the gamma delta T cell lines demonstrated a proliferation and production of IFN-gamma that exceeded that of BCG-specific Th1-type T cell clones (mean stimulation index: 14.5 vs. 2.8, mean IFN-gamma: 130.5 vs. 10.0 pg/mL). When the gamma delta T cell lines and mite-allergen-specific Th2 clones were co-cultured with each other, only the levels of IL-4 (mean, -87%) de
DOI	10.1111/j.1365-2222.2007.02826.x