コレマツ　セイゴ   KOREMATSU Seigo   是松　聖悟    所属   埼玉医科大学  医学部 総合医療センター　小児科（小児科､総合周産期母子医療センター新生児科、小児救命救急センター）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	A relapse of systemic type juvenile idiopathic arthritis after a rubella vaccination in a patient during a long-term remission period.
掲載誌名	正式名：Vaccine ISSNコード：0264410X
出版社	ELSEVIER SCI LTD
巻・号・頁	27(37),5041-2頁
著者・共著者	Seigo Korematsu,Hiroaki Miyahara,Tatsuya Kawano,Hiroshi Yamada,Kensuke Akiyoshi,Keisuke Sato,Tomoki Maeda,So-ichi Suenobu,Tatsuro Izumi
発行年月	2009/08
概要	An 11-year-old female patient, whose systemic type juvenile idiopathic arthritis (JIA) had maintained in remission for the previous 4 years while taking only a small amounts of ibuprofen, showed an abrupt 2nd relapse with congestive heart failure five days after receiving a live-attenuated rubella vaccine, which was a primary immunization. Her serum levels of anti-rubella IgM and IgG antibodies increased, and her laboratory findings such as a leukocytosis, elevated serum levels of CRP, IL-6 and other inflammatory cytokine profiles were similar to the findings observed during her previous JIA active stage. After being administration of co-therapy with steroid pulse, ibuprofen, methotrexate and phosphodiesterase inhibitor gradually improved her clinical symptoms such as spiky fever, heart failure and arthralgia. Her intermittent fever and increased serum levels of CRP and IL-6, however, have been sustained for more than 2 years, and this prolonged active clinical course therefore differed from her previous JIA active stage.This abrupt relapse only five days after vaccination was suggested not to be directly related with rubella infection, but instead to be related with the molecular
DOI	10.1016/j.vaccine.2009.06.052
PMID	19576941