ヨゴサワ　シンゴ   YOGOSAWA Shingo   与五沢　真吾    所属   埼玉医科大学  保健医療学部 臨床検査学科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Lysocellin, a metabolite of the novel drug 'alopestatin', induces G1 arrest and prevents cytotoxicity induced by etoposide
掲載誌名	正式名：INTERNATIONAL JOURNAL OF ONCOLOGY ISSNコード：1019-6439
出版社	PROFESSOR D A SPANDIDOS
巻・号・頁	28(4),823-829頁
著者・共著者	Y Takahara,S Yogosawa,S Maruyama,N Watanabe,H Yokoyama,K Fukasawa,Y Sukenaga,J Kamiyama,M Izumi,M Wakada,HL Zhang,K Yoshizawa,S Kawa,T Nikaido,T Sakai
発行年月	2006/04
概要	We report here that lysocellin, a polyether antibiotic from a streptomycete, induces G1 phase arrest in human osteosarcoma MG63 cells. Lysocellin up-regulates p21(WAF1/Cip1) and down-regulates cyclin D1 at the mRNA level. In addition, cyclin D1 is down-regulated by the proteasome-dependent signal pathway in MG63 cells. In drug combination studies, we found that lysocellin treatment weakened the cytotoxic activity of etoposide in MG63 cells using a colony-formation assay. To study the in vivo efficacy of lysocellin, we isolated a novel compound related to lysocellin from the same streptomycete, and found that the novel drug is converted to lysocellin in vivo and decreases etoposide-induced alopecia in a neonatal rat model. We raise the possibility that this novel drug, named 'alopestatin', may be a promising agent against alopecia.
PMID	16525630