キャン　リョウコ   KYAN Ryoko   喜屋武　玲子    所属   埼玉医科大学  医学部 臨床中毒科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Mechanism of central hypopnoea induced by organic phosphorus poisoning.
掲載誌名	正式名：Scientific Reports
掲載区分	国外
巻・号・頁	10(1),15834頁
著者・共著者	Nomura K, Narimatsu E, Inoue H, Kyan R, Sawamoto K, Uemura S, Kakizaki R, Harada K.
発行年月	2020/09/28
概要	we established a paraoxon (a typical acetylcholinesterase inhibitor) poisoning model to investigate the time-dependent changes in respiratory burst amplitudes of the pre-Bötzinger complex (respiratory rhythm generator). We then determined whether pralidoxime or atropine, which are antidotes of paraoxon, could counteract the effects of paraoxon. Herein, we showed that paraoxon significantly decreased the respiratory burst amplitude of the pre-Bötzinger complex (p < 0.05). Moreover, pralidoxime and atropine could suppress the decrease in amplitude by paraoxon (p < 0.05). Paraoxon directly impaired the pre-Bötzinger complex, and the findings implied that this impairment caused central apnoea or hypopnoea. Pralidoxime and atropine could therapeutically attenuate the impairment. This study is the first to prove the usefulness of the multi-electrode array method for electrophysiological and toxicological studies in the mammalian brainstem.